As time flies by: Investigating cardiac aging in the short-lived Drosophila model
As time flies by: Investigating cardiac aging in the short-lived Drosophila model
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DOI：
10.1016/j.bbadis.2018.11.010
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发表时间：
2019-07-01
影响因子：
6.2
通讯作者：
Cammarato，Anthony
中科院分区：
文献类型：
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作者：
Blice-Baum，Anna C.;Guida，Maria Clara;Cammarato，Anthony
衰老与心脏功能在组织、细胞和分子水平上的下降有关。随着时间的推移，心血管疾病的风险显著增加，随着发达国家的寿命继续增加，老年人心血管保健的成本无疑会上升。心功能随年龄增长而恶化的分子基础是多方面的，并不完全清楚，在人类受试者或哺乳动物模型上进行的研究是有限的。黑腹果蝇已成为研究短时间内衰老的有用模式生物，得益于一套分子和遗传工具，并显示出高度保守的心脏衰老特征。在这里，我们讨论了我们对心脏衰老的理解的最新进展，以及果蝇如何在这些发展中发挥作用。
Aging is associated with a decline in heart function across the tissue, cellular, and molecular levels. The risk of cardiovascular disease grows significantly over time, and as developed countries continue to see an increase in lifespan, the cost of cardiovascular healthcare for the elderly will undoubtedly rise. The molecular basis for cardiac function deterioration with age is multifaceted and not entirely clear, and there is a limit to what investigations can be performed on human subjects or mammalian models.Drosophila melanogasterhas emerged as a useful model organism for studying aging in a short timeframe, benefitting from a suite of molecular and genetic tools and displaying highly conserved traits of cardiac senescence. Here, we discuss recent advances in our understanding of cardiac aging and how the fruit fly has aided in these developments.