Short and long term reproducibility of responsiveness to inhaled histamine: Rt compared to FEV1 as measurement of response to challenge.
Short and long term reproducibility of responsiveness to inhaled histamine: Rt compared to FEV1 as measurement of response to challenge.
复制标题
对吸入组胺反应的短期和长期重现性：Rt 与 FEV1 相比，作为对挑战反应的测量。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
B. Weeke
中科院分区：
文献类型：
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作者：
F. Madsen;N. H. Rathlou;L. Frølund;U. Svendsen;B. Weeke
通过中断器法测定的 FEV1 和呼吸阻力 (Rt)，在选定的稳定哮喘患者和非哮喘患者组中测试了吸入组胺反应的重复性（123 分钟）和再现性（65 天）。攻击前 FEV1 和 Rt 的变化分别保持在 +/- 10% 和 +/- 40% 范围内。我们发现 123 分钟后 PC20-FEV1 具有高度可重复性。单次测定的 95% 置信区间为测量值 +/- 1.72 两倍浓度差异。重现性明显较低（p 小于 0.05）。 PC30-Rt的重复性和再现性均显着低于PC20-FEV1。中断器法测定的 PC30-Rt 被发现在 4 个两倍浓度差异内可重复，这对于临床和研究目的来说是不可接受的。 PC30-Rt 的重复性差可能是由于挑战过程中功能残余容量的变化所致。
Repeatability (123 min) and reproducibility (65 days) of response to inhaled histamine were tested in a selected group of stable asthmatics and non-asthmatics by means of FEV1 and breathing resistance (Rt) determined by the interruptor method. Variation in prechallenge FEV1 and Rt was kept within a +/- 10% and +/- 40% range, respectively. We found the PC20-FEV1 highly repeatable after 123 min. The 95% confidence interval for a single determination was the measured value +/- 1.72 two-fold concentration differences. Reproducibility was significantly lower (p less than 0.05). Both repeatability and reproducibility of PC30-Rt were significantly lower than that of PC20-FEV1. Interruptor method determined PC30-Rt was found repeatable within 4 two-fold concentration differences which is not acceptable for clinical and research purposes. The poor repeatability of PC30-Rt could be due to changes in functional residual capacity during challenge.