Reduction of normal lung irradiation in locally advanced non-small-cell lung cancer patients, using ventilation images for functional avoidance
Reduction of normal lung irradiation in locally advanced non-small-cell lung cancer patients, using ventilation images for functional avoidance
复制标题
DOI：
10.1016/j.ijrobp.2007.01.044
复制
发表时间：
2007-06-01
影响因子：
7
通讯作者：
Komaki, Ritsuko
中科院分区：
文献类型：
--
作者：
Yaremko, Brian P.;Guerrero, Thomas M.;Komaki, Ritsuko
目的：探讨四维计算机断层扫描（4D-CT）衍生的通气图像识别高功能肺区域的能力，以避免局部晚期非小细胞肺癌（NSCLC）的调强放疗（IMRT）计划。方法和材料：选择21例III期NSCLC患者的治疗计划记录。从4D-CT组生成通气图像，并将每个图像导入治疗计划系统。生成第90百分位数功能容积（PFV 90），其构成发生最高通气的肺容积的10%。使用V20上的肺容量限制生成基线IMRT计划（
Purpose: To investigate the ability of four-dimensional computed tomography (4D-CT)-derived ventilation images to identify regions of highly functional lung for avoidance in intensity-modulated radiotherapy (IMRT) planning in locally advanced non-small-cell lung cancer (NSCLC).Methods and Materials: The treatment-planning records from 21 patients with Stage III NSCLC were selected. Ventilation images were generated from the 4D-CT sets, and each was imported into the treatment-planning system. Ninetieth percentile functional volumes (PFV90), constituting the 10% of the lung volume where the highest ventilation occurs, were generated. Baseline IMRT plans were generated using the lung volume constraint on V20 (