THE EFFECTS OF AGE AND ALCOHOL ON (Na++ K+)‐ATPASE ACTIVITY OF WHOLE HOMOGENATE AND SYNAPTOSOMES PREPARED FROM MOUSE AND HUMAN BRAIN
THE EFFECTS OF AGE AND ALCOHOL ON (Na++ K+)‐ATPASE ACTIVITY OF WHOLE HOMOGENATE AND SYNAPTOSOMES PREPARED FROM MOUSE AND HUMAN BRAIN
复制标题
年龄和酒精对小鼠和人脑制备的全匀浆和突触体 (Na++ K+)-ATP酶活性的影响
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
T. Samorajski
中科院分区：
文献类型：
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作者：
A. Sun;T. Samorajski
在代表成熟和老年的不同年龄水平，获得了小鼠脑的完整匀浆以及小鼠和人脑的神经末梢部分。小鼠3、8、26~29个月龄，人19~84岁，小鼠全脑匀浆中(Na~++K~+)-ATPase的测定与年龄无显著差异。然而，在老年小鼠和人类中，不同浓度的乙醇抑制膜结合的突触体(Na++K+)-ATPase的能力明显更强。这些数据被解释为表明随着年龄的增长，突触膜的性质发生了变化。
Whole homogenates of mouse brain and nerve‐ending fractions of mouse and human brain were obtained at various age levels representative of maturity and old age. The mice were 3, 8 and 26–29 months old and the humans ranged in age from 19 to 84 y. Measurements of (Na++ K+)‐ATPase in whole brain homogenate of mouse did not reveal any significant differences in relation to age. However, the ability of ethanol at various concentrations to inhibit membrane‐bound synaptosomal (Na++ K+)‐ATPase was significantly greater in older mice and humans. The data are interpreted as indicating a change in the property of synaptic membranes as a consequence of advancing age.