A STUDY OF AFFERENT-PROJECTIONS TO THE RAT INTERPEDUNCULAR NUCLEUS
A STUDY OF AFFERENT-PROJECTIONS TO THE RAT INTERPEDUNCULAR NUCLEUS
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DOI：
10.1016/0361-9230(84)90035-2
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发表时间：
1984-01-01
影响因子：
3.8
通讯作者：
JACOBOWITZ, DM
中科院分区：
文献类型：
--
作者：
HAMILL, GS;JACOBOWITZ, DM
前脑和脑干传入投射到脚间核（IPN）的表现在雄性大鼠逆行运输的荧光染料，快蓝，显微注射在IPN，然后在脑室内秋水仙碱灌注前48小时。最强烈的标记细胞投射到IPN集中在整个内侧缰核的吻尾侧范围。少数标记的内侧缰细胞位于背内侧也显示SP [P物质]免疫荧光。另外的前脑传入神经来源于隔核、下丘脑和乳头核。投射到IPN的脑干传入，最强烈的标记神经元存在于一个限定的区域覆盖背侧被盖核的背侧，在猫的一个区域描述为核incertus。在这个核的内侧面的许多标记细胞也显示L-ENK [leu-enkephalin]免疫荧光。其他传入神经包括中缝核、背外侧被盖核和蓝斑。前脑和脑干传入纤维都投射到IPN。内侧缰核和未定核分别有和L-ENK投射。
Forebrain and brainstem afferents projecting to the interpeduncular nucleus (IPN) were demonstrated in male rats by retrograde transport of fluorescent dye, fast blue, microinjected in IPN, followed by intraventricular colchicine 48 h prior to perfusion. The most intensely labeled cells projecting to IPN were concentrated throughout the entire rostrocaudal extent of the medial habenular nuclei. A small number of labeled medial habenular cells located dorsomedially also revealed SP [substance P] immunofluorescence. Additional forebrain afferents originate from septal, hypothalamic and mammillary nuclei. Of brainstem afferents projecting to IPN, the most intensely labeled neurons were present in a circumscribed region overlying the dorsal aspect of the dorsal tegmental nucleus, an area described in the cat as the nucleus incertus. Many labeled cells in the medial aspect of this nucleus also revealed L-ENK [leu-enkephalin] immunofluorescence. Additional afferents include the raphe, dorsolateral tegmental nuclei and locus coeruleus. Both forebrain and brainstem afferents project to IPN. There are and L-ENK projections from the medial habenula and nucleus incertus, respectively.