Flavoprotein autofluorescence detection of early ocular dysfunction
Flavoprotein autofluorescence detection of early ocular dysfunction
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DOI：
10.1001/archophthalmol.2007.44
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发表时间：
2008-02-01
影响因子：
--
通讯作者：
Petty, Howard R.
中科院分区：
文献类型：
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作者：
Elner, Victor M.;Park, Seung;Petty, Howard R.
代谢应激在疾病发作时发生，并导致黄素蛋白氧化还原活性改变，从而增加黄素蛋白自发荧光（FA）。使用一种新的方法来测量眼部FA，我们研究了由于假性脑瘤而导致轻微视觉功能障碍的女性。每个FA值是更大的每一个女性患假性脑瘤，在每一个案件中，允许识别的眼睛。黄素蛋白自发荧光值平均60%以上，更多受影响的眼睛与假性脑瘤的妇女，但不是眼睛之间的健康妇女（对照组）。这些结果表明FA的临床效用，并可能允许早期检测和监测视网膜和视神经疾病。
Metabolic stress occurs at disease onset and causes altered flavoprotein redox activity that increases flavoprotein autofluorescence (FA). Using a new method to measure ocular FA, we studied women with subtle visual dysfunction due to pseudo-tumor cerebri. Each FA value was greater in the more affected eye of each woman with pseudotumor cerebri, permitting identification of that eye in each case. Flavoprotein autofluorescence values averaged 60% greater in more affected eyes of women with pseudotumor cerebri, but not between eyes of healthy women (control subjects). These results demonstrate the clinical utility of FA and may permit early detection and monitoring of retinal and optic nerve diseases.