RADIOTHERAPY ALONE VERSUS COMBINED CHEMOTHERAPY AND RADIOTHERAPY IN NONRESECTABLE NON-SMALL-CELL LUNG-CANCER - 1ST ANALYSIS OF A RANDOMIZED TRIAL IN 353 PATIENTS
RADIOTHERAPY ALONE VERSUS COMBINED CHEMOTHERAPY AND RADIOTHERAPY IN NONRESECTABLE NON-SMALL-CELL LUNG-CANCER - 1ST ANALYSIS OF A RANDOMIZED TRIAL IN 353 PATIENTS
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DOI：
10.1093/jnci/83.6.417
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发表时间：
1991-03-20
影响因子：
10.3
通讯作者：
LAPLANCHE, A
中科院分区：
文献类型：
--
作者：
LECHEVALIER, T;ARRIAGADA, R;LAPLANCHE, A
我们报告了一项大型随机研究中观察到的结果，该研究比较了单独放疗（标准治疗）与放疗和化疗联合治疗不可切除的鳞状细胞癌和大细胞肺癌的效果。放疗剂量均为65戈伊，化疗包括长春地辛、环磷酰胺、顺铂和洛莫司汀。本研究中，177例患者接受单独放疗（A组），176例患者接受联合治疗（B组）。2年生存率A组为14%，B组为21%（P = 0.08）。B组远处转移率明显低于对照组（P <0.001）。两组的局部控制都很差（分别为17%和15%），仍然是主要问题。
We report the results observed in a large, randomized study that compared the effects of radiotherapy alone (the standard therapy) with those of a combination of radiotherapy and chemotherapy in nonresectable squamous cell and large-cell lung carcinoma. The radiation dose was 65 Gy in each group, and chemotherapy included vindesine, cyclophosphamide, cisplatin, and lomustine. In this study, 177 patients received radiotherapy alone (group A), and 176 patients received the combined treatment (group B). The 2-year survival rate was 14% in group A and 21% in group B (P = .08). The distant metastasis rate was significantly lower in group B (P < .001). Local control was poor in both groups (17% and 15%, respectively) and remained the major problem.