Individual effects of estrogens on a marine fish, Cunner (Tautogolabrus adspersus), extrapolated to the population level
Individual effects of estrogens on a marine fish, Cunner (Tautogolabrus adspersus), extrapolated to the population level
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DOI：
10.1016/j.ecoenv.2005.05.017
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发表时间：
2006-02-01
影响因子：
6.8
通讯作者：
Mills, LJ
中科院分区：
文献类型：
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作者：
Gutjahr-Gobell, RE;Zaroogian, GE;Mills, LJ
环境中的内分泌干扰化学物质（EDC）可能会通过影响繁殖产量来改变野生动物的种群动态。本研究描述了一种矩阵建模方法，将内分泌干扰的实验室研究与潜在的生态影响联系起来。使用的实验模型是 cunner (Tautogolabrus adspersus)，它栖息在污水处理和其他可能含有雌激素 EDC 的排放物的河口和海洋区域。为了测试雌激素暴露对生育能力的影响，在三个独立的实验中，通过以 0.05、0.5 和 2.5 mg/kg 的剂量在缓释基质中皮下植入 17 β-雌二醇、雌酮或 17 α-乙炔雌二醇，对生殖活跃的 cunner 进行暴露。在 1 周预暴露期和随后 2 周暴露期，每天测定每克雌性的产蛋量和卵活力。计算每个实验的初始预暴露期和两周暴露期的每克雌性产卵的平均数量和卵活力（%）。在高 17 β-雌二醇治疗（P = 0.07）和高 17 α-乙炔雌二醇治疗（P = 0.04）中，观察到每克雌性产蛋量的显着变化。在低 17 α-乙炔雌二醇治疗中，观察到卵子活力 (%) 显着增加（39.0%；P
Endocrine-disrupting chemicals (EDCs) in the environment may alter the population dynamics of wildlife by affecting reproductive output. This study describes a matrix modeling approach to link laboratory studies on endocrine disruption with potential ecological effects. The experimental model used is cunner (Tautogolabrus adspersus), which inhabit estuarine and marine areas where sewage treatment and other discharges containing estrogenic EDCs are likely. To test the effects of estrogenic exposures on fecundity, reproductively active cunner were exposed in three separate experiments by implanting 17 beta-estradiol, estrone, or 17 alpha-ethynylestradiol subcutaneously in a slow-release matrix at 0.05, 0.5, and 2.5 mg/kg. Egg production per gram female and egg viability were determined daily for a 1-week preexposure period and then for a 2-week exposure period. The mean number of eggs produced per gram female and egg viability (%) were calculated for the initial preexposure period and the 2-week exposure period for each experiment. Significant changes were observed in egg production per gram female in the high-17 beta-estradiol treatment (P = 0.07) and high-17 alpha-ethynylestradiol treatment (P = 0.04). A significant increase was observed in egg viability (%) in the low-17 alpha-ethynylestradiol treatment (39.0%; P