Antibodies have the intrinsic capacity to destroy antigens.
Antibodies have the intrinsic capacity to destroy antigens.
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DOI：
10.1073/pnas.97.20.10930
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发表时间：
2000-09
影响因子：
11.1
通讯作者：
A. D. Wentworth;Lyn H. Jones;P. Wentworth;Kim D. Janda;Richard A. Lerner
中科院分区：
文献类型：
--
作者：
A. D. Wentworth;Lyn H. Jones;P. Wentworth;Kim D. Janda;Richard A. Lerner
上个世纪的研究已经就免疫系统的体液成分的策略达成了共识。其实质是，为了杀死抗体，抗体分子激活了对抗体-抗原结合做出反应的额外系统。我们现在报告说，免疫系统似乎有一个以前未认识到的化学势固有的抗体分子本身。研究的所有抗体，无论来源或抗原特异性如何，都可以将分子氧转化为过氧化氢，从而可能在同一分子内对齐识别和杀伤。除了指出免疫系统的一个新的化学武器外，这些结果可能对理解抗体如何进化以及它们在人类疾病中可能发挥的作用很重要。
Research throughout the last century has led to a consensus as to the strategy of the humoral component of the immune system. The essence is that, for killing, the antibody molecule activates additional systems that respond to antibody-antigen union. We now report that the immune system seems to have a previously unrecognized chemical potential intrinsic to the antibody molecule itself. All antibodies studied, regardless of source or antigenic specificity, can convert molecular oxygen into hydrogen peroxide, thereby potentially aligning recognition and killing within the same molecule. Aside from pointing to a new chemical arm for the immune system, these results may be important to the understanding of how antibodies evolved and what role they may play in human diseases.