Multiscale Adaptive Regression Models for Neuroimaging Data.
Multiscale Adaptive Regression Models for Neuroimaging Data.
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DOI:
10.1111/j.1467-9868.2010.00767.x
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发表时间:
2011-09
期刊:
影响因子:
--
通讯作者:
Ibrahim JG
中科院分区:
文献类型:
--
作者:
Li Y;Zhu H;Shen D;Lin W;Gilmore JH;Ibrahim JG
Neuroimaging studies aim to analyze imaging data with complex spatial patterns in a large number of locations (called voxels) on a two-dimensional (2D) surface or in a 3D volume. Conventional analyses of imaging data include two sequential steps: spatially smoothing imaging data and then independently fitting a statistical model at each voxel. However, conventional analyses suffer from the same amount of smoothing throughout the whole image, the arbitrary choice of smoothing extent, and low statistical power in detecting spatial patterns. We propose a multiscale adaptive regression model (MARM) to integrate the propagation–separation (PS) approach with statistical modeling at each voxel for spatial and adaptive analysis of neuroimaging data from multiple subjects. MARM has three features: being spatial, being hierarchical, and being adaptive. We use a multiscale adaptive estimation and testing procedure (MAET) to utilize imaging observations from the neighboring voxels of the current voxel to adaptively calculate parameter estimates and test statistics. Theoretically, we establish consistency and asymptotic normality of the adaptive parameter estimates and the asymptotic distribution of the adaptive test statistics. Our simulation studies and real data analysis confirm that MARM significantly outperforms conventional analyses of imaging data.
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影响因子:
2
作者:
Polzehl, J;Spokoiny, V
通讯作者:
Spokoiny, V
影响因子:
5.7
作者:
Tabelow, Karsten;Polzehl, Joerg;Voss, Henning U.
通讯作者:
Voss, Henning U.
影响因子:
5.7
作者:
Tabelow, Karsten;Polzehl, Joerg;Spokoiny, Vladimir
通讯作者:
Spokoiny, Vladimir
DOI:
10.1111/j.2517-6161.1995.tb02031.x
发表时间:
1995-01-01
影响因子:
5.8
作者:
BENJAMINI, Y;HOCHBERG, Y
通讯作者:
HOCHBERG, Y
影响因子:
10.6
作者:
Tabelow, K.;Polzehl, J.;Voss, H. U.
通讯作者:
Voss, H. U.