The effect of PPARγ ligands on the adipose tissue in insulin resistance
The effect of PPARγ ligands on the adipose tissue in insulin resistance
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DOI：
10.1016/j.plefa.2005.04.008
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发表时间：
2005-07-01
影响因子：
3
通讯作者：
Smith, U
中科院分区：
文献类型：
--
作者：
Hammarstedt, A;Andersson, CX;Smith, U
胰岛素抵抗经常伴随肥胖，肥胖和2型糖尿病都与轻度慢性炎症有关。在这些病症中，通常在脂肪组织中发现升高水平的各种细胞因子，如TNF-α和IL-6。已经表明，脂肪组织中产生的许多细胞因子来源于浸润的炎性细胞。然而，脂肪组织本身已被证明是一个重要的内分泌器官，分泌几种激素和细胞因子，通常被称为脂肪因子。过氧化物酶体增殖物激活受体（PPAR）γ是脂肪细胞增殖和分化所必需的。近年来，过氧化物酶体增殖物激活受体γ及其配体噻唑烷二酮类化合物（TZD）由于具有胰岛素增敏和抗炎作用而受到广泛关注。TZD治疗可改善胰岛素信号传导和脂肪细胞分化，增加脂肪组织中游离脂肪酸的流入，并抑制细胞因子的表达和作用。因此，PPAR γ在维持功能性和分化的脂肪组织中起核心作用。(c)2005爱思唯尔有限公司保留所有权利。
Insulin resistance is frequently accompanied by obesity and both obesity and type 2 diabetes are associated with a mild chronic inflammation. Elevated levels of various cytokines, such as TNF-alpha and IL-6, are typically found in the adipose tissue in these conditions. It has been suggested that many cytokines produced in the adipose tissue are derived from infiltrated inflammatory cells. However, the adipose tissue itself has proven to be an important endocrine organ, secreting several hormones and cytokines, usually referred to as adipokines. Peroxisome proliferator-activated receptor (PPAR)gamma is essential for adipocyte proliferation and differentiation. In recent years, PPAR gamma and its ligands, the thiazolidinediones (TZD), have achieved great attention due to their insulin sensitizing and anti-inflammatory properties. Treatment with TZDs result in improved insulin signaling and adipocyte differentiation, increased adipose tissue influx of free fatty acids and inhibition of cytokine expression and action. As a result, PPAR gamma plays a central role in maintaining a functional and differentiated adipose tissue. (c) 2005 Elsevier Ltd. All rights reserved.