IL-32: a newly-discovered proinflammatory cytokine.
IL-32: a newly-discovered proinflammatory cytokine.
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发表时间：
2009-07
影响因子：
3.2
通讯作者：
P. Felaco;M. L. Castellani;De Lutiis Ma;M. Felaco;Franco Pandolfi;Salini;D. DeAmicis;Jacopo Vecchiet;Stefano Tetè;C. Ciampoli;F. Conti;G. Cerulli;A. Caraffa;P. Antinolfi;C. Cuccurullo;A. Perrella;T. C. Theoharides;Peter S. Conti;E. Toniato;D. Kempuraj;Y. Shaik
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文献类型：
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作者：
P. Felaco;M. L. Castellani;De Lutiis Ma;M. Felaco;Franco Pandolfi;Salini;D. DeAmicis;Jacopo Vecchiet;Stefano Tetè;C. Ciampoli;F. Conti;G. Cerulli;A. Caraffa;P. Antinolfi;C. Cuccurullo;A. Perrella;T. C. Theoharides;Peter S. Conti;E. Toniato;D. Kempuraj;Y. Shaik
IL-32是一种新发现的促炎细胞因子，可激活p38 MAPK和NF-κ B通路，在先天性和适应性免疫应答中发挥重要作用。IL-32是一种主要由T细胞、自然杀伤细胞和上皮细胞产生的细胞因子，其诱导显著量的TNF α和MIP-2，并以剂量依赖性方式增加两种细胞因子的产生。IL-32与炎症性疾病、结核分枝杆菌感染、炎症性肠病和甲型流感病毒感染以及一些自身免疫性疾病如类风湿性关节炎、溃疡性结肠炎和克罗恩病有关。的疾病和人胃癌、人肺癌和乳腺癌组织中。此外，据报道，IL-32对骨髓细胞具有促炎作用，并导致破骨细胞前体分化为表达特异性破骨细胞标志物的多核细胞。我们最近发现，人IL-32有能力引起组胺释放的人源性脐带血肥大细胞（HDCBMC），但不是在LAD 2细胞和大鼠腹膜肥大细胞（RPMC），表明IL-32可能是物种特异性的，并在成熟的人肥大细胞（HDCBMC）比在转化肥大细胞（LAD 2细胞）。当然，IL-32是另一种有效的促炎细胞因子，然而，这种新发现的蛋白质在细胞因子生物学网络中的具体作用仍有待确定。
IL-32, a newly-discovered proinflammatory cytokine that activates the p38MAPK and NF-kappaB pathways, is an important player in innate and adaptive immune response. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis and Crohn?s disease and in human stomach cancer, human lung cancer and breast cancer tissues. Moreover, it has been reported that IL-32 has pro-inflammatory effects on myeloid cells and causes the differentiation of osteoclast precursors into multinucleated cells expressing specific osteoclast markers. We recently found that human IL-32 has the capacity to provoke histamine release in human-derived cord blood mast cells (HDCBMC), but not in LAD 2 cells nor in rat peritoneal mast cells (RPMC), showing that IL-32 may be specie specific and act more in mature human mast cells (HDCBMC) than in transformed mast cells (LAD 2 cells). Certainly, IL-32 is another potent proinflammatory cytokine, however, the specific role of this newly-discovered protein in the network of cytokine biology remains to be determined.