2ND PRIMARY-CANCER FOLLOWING LARYNGEAL-CANCER WITH SPECIAL REFERENCE TO SMOKING-HABITS
2ND PRIMARY-CANCER FOLLOWING LARYNGEAL-CANCER WITH SPECIAL REFERENCE TO SMOKING-HABITS
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DOI：
10.1111/j.1349-7006.1992.tb00111.x
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发表时间：
1992-04-01
期刊：
影响因子：
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通讯作者：
FUJIMOTO, I
中科院分区：
文献类型：
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作者：
HIYAMA, T;SATO, T;FUJIMOTO, I
通过与大阪癌症登记处的记录关联，对 472 名男性喉癌患者平均随访 8.6 年，评估了喉癌后发生第二原发癌症的风险。在这些患者中，有 115 名患上喉癌以外的第二种癌症，而根据大阪居民的发病率得出的预期数字为 51.4（相对风险 (RR) = 2.2，95% 置信区间 = 1.85-2.69）。喉癌 15 年后发生第二原发癌症的累积风险估计为 31.1%。按部位划分，与烟草相关的癌症风险显着增加，口腔癌、咽癌、食道癌和肺癌的 RR 分别为 24.5、6.1 和 2.3。此外，重度吸烟者患口腔癌、咽癌和食道癌的风险高于轻度吸烟者。没有观察到喉癌放疗对甲状腺癌、淋巴瘤和白血病的发展产生不良影响。本研究表明有必要对喉癌患者进行长期随访，以便及早发现与烟草相关的癌症。
The risk of developing a second primary cancer following laryngeal cancer was estimated by following-up 472 male laryngeal cancer patients for an average of 8.6 years by means of record linkage to the Osaka Cancer Registry. Of these patients, 115 developed a second cancer other than laryngeal cancer, whereas the expected number derived from the incidence rates among Osaka residents was 51.4 (relative risk (RR) = 2.2, 95% confidence interval = 1.85-2.69). Cumulative risk of developing a second primary cancer was estimated to be 31.1% at 15 years after laryngeal cancer. By site, the risks were significantly increased for tobacco-related cancers, RR = 24.5, 6.1 and 2.3 for cancers of the oral cavity & pharynx, esophagus and lung, respectively. Also, the risks were higher among heavy smokers for cancer of the oral cavity & pharynx and esophagus than among light smokers. No adverse effects of radiotherapy for laryngeal cancer on the development of thyroid cancer, lymphoma and leukemia were observed. The present study suggests the necessity of following-up laryngeal cancer patients over a long period in order to enable the early detection of tobacco-related cancer.