Two-stage maturation process for newly replicated chromatin.
Two-stage maturation process for newly replicated chromatin.
复制标题
新复制的染色质的两阶段成熟过程。
DOI：
10.1021/bi00302a036
复制
发表时间：
1984
期刊：
影响因子：
2.9
通讯作者：
Chalkley,R
中科院分区：
文献类型：
--
作者：
Smith,PA;Jackson,V;Chalkley,R
对复制叉附近真核染色质结构的研究表明，与该 DNA 区域相关的核小体的性质不同于与非复制 DNA 相关的核小体的性质。 DNA 合成后 5-25 分钟内，这些不成熟的核小体会发生重排，从而获得大量或成熟染色质的结构特性 (DePamphilis & Wassarman, 1980)。与未成熟染色质相关的一些结构特征包括较低的浮力密度、
Studies investigating the structure of eucaryotic chromatin in the vicinity of the replication fork have shown that the nature of nucleosomes associated with thisregion of DNA differs from that seen for nucleosomes associated with non-replicating DNA. Within 5-25 min of DNA synthesis, these immature nucleosomes undergo a rearrangement in which they attain the structural properties of bulk or mature chromatin (DePamphilis & Wassarman, 1980). Some of the structural characteristics associated with im-mature chromatin include a lower buoyant density, an in-