Retinal waves: mechanisms and function in visual system development
Retinal waves: mechanisms and function in visual system development
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DOI：
10.1016/j.ceca.2005.01.010
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发表时间：
2005-05-01
期刊：
影响因子：
4
通讯作者：
Feller, MB
中科院分区：
文献类型：
--
作者：
Firth, SI;Wang, CT;Feller, MB
发展中的神经网络的一个特征是自发的周期性活动。在发育中的视网膜中，视网膜神经节细胞发射动作电位，以分钟为周期驱动细胞内钙浓度的大量增加。这些动作电位的周期性爆发以波的形式在发育中的视网膜内传播，驱动邻近的视网膜神经节细胞以相关的方式放电。在这里，我们将回顾最近在阐明哺乳动物视网膜波传播的机制和那些调节视网膜波发生的周期性的机制方面的进展。此外，我们将回顾最近的实验表明，视网膜波是至关重要的精炼视网膜投影到他们的主要目标在中央视觉系统，并可能参与驱动视网膜本身的发育过程。(c) 2005 Elsevier Ltd版权所有。
A characteristic feature of developing neural networks is spontaneous periodic activity. In the developing retina, retinal ganglion cells fire bursts of action potentials that drive large increases in intracellular calcium concentration with a periodicity of minutes. These periodic bursts of action potentials propagate across the developing inner retina as waves, driving neighboring retinal ganglion cells to fire in a correlated fashion. Here we will review recent progress in elucidating the mechanisms in mammals underlying retinal wave propagation and those regulating the periodicity with which these retinal waves occur. In addition, we will review recent experiments indicating that retinal waves are critical for refining retinal projections to their primary targets in the central visual system and may be involved in driving developmental processes within the retina itself. (c) 2005 Elsevier Ltd. All rights reserved.