A population-based analysis of survival factors in differentiated and medullary thyroid carcinoma
A population-based analysis of survival factors in differentiated and medullary thyroid carcinoma
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DOI：
10.1067/mhn.2003.2
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发表时间：
2003-01-01
影响因子：
3.4
通讯作者：
Bhattacharyya, N
中科院分区：
文献类型：
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作者：
Bhattacharyya, N
目的：本研究的目的是确定分化型甲状腺癌（DTC）的生存和预后因素。方法：DTC的情况下，从1988年至1998年的监测，流行病学和最终结果数据库中提取。对乳头状、滤泡和髓质组织学进行Kaplan-Meier生存分析。考克斯比例风险分析被用来研究年龄，性别，肿瘤大小，局部扩展，和颈部淋巴结的参与对总survival.Results的影响：共18,118例被确定，包括15;820（87.3%）乳头状癌，1799（9.9%）滤泡癌，499（2.8%）髓样癌。乳头状、滤泡状和髓样肿瘤的平均生存期（10年生存率）分别为122（87.7%）、117（80.2%）和108（73.7%）个月。对于每种组织学，增加年龄，男性性别，和局部扩展程度大大降低生存。颈部转移不影响生存的乳头状癌或滤泡状癌，但接近髓样癌的意义（P = 0：065）。结论：在甲状腺癌的局部扩展程度应细分，以更准确地确定预后。甲状腺髓样癌应考虑颈部治疗。
OBJECTIVE: The study purpose was to determine survival and prognostic factors for differentiated thyroid carcinoma (DTC).METHODS: Cases of DTC were extracted from the Surveillance, Epidemiology and End Results database from 1988 through 1998. Kaplan-Meier survival analysis was conducted for papillary, follicular, and medullary histologies. Cox proportional hazard analysis was used to examine the influence of age, gender, tumor size, local extension, and cervical node involvement on overall survival.RESULTS: A total of 18,118 cases were identified, including 15;820 (87.3%) papillary carcinomas, 1799 (9.9%) follicular carcinomas, and 499 (2.8%) medullary carcinomas. Mean survival (10-year survival) was 122 (87.7%),117 (80.2%), and 108 (73.7%) months for papillary, follicular, and medullary tumors, respectively.. For each histology, increasing age, male gender, and degree of local extension substantially reduced survival. Cervical metastasis did not influence survival for papillary or follicular carcinomas but approached significance for medullary carcinoma (P = 0:065).CONCLUSIONS: Degree of local extension in thyroid carcinoma should be subclassified to more accurately determine prognosis. Treatment of the neck should be considered for medullary thyroid carcinoma.