Antitumor effects of saffron-derived carotenoids in prostate cancer cell models.
Antitumor effects of saffron-derived carotenoids in prostate cancer cell models.
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藏红花衍生的类胡萝卜素在前列腺癌细胞模型中的抗肿瘤作用。
DOI：
10.1155/2014/135048
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发表时间：
2014
影响因子：
--
通讯作者：
Carmona M
中科院分区：
文献类型：
--
作者：
Festuccia C;Mancini A;Gravina GL;Scarsella L;Llorens S;Alonso GL;Tatone C;Di Cesare E;Jannini EA;Lenzi A;D'Alessandro AM;Carmona M
番红花提取物(藏红花)富含类胡萝卜素。临床前研究表明，饮食摄入类胡萝卜素具有抗肿瘤作用，这表明它们具有潜在的预防和/或治疗作用。我们最近报道了藏红花(SE)和西红花(CR)通过促进前列腺癌(PCA)细胞周期停滞而显示出抗癌活性。也有研究表明，西红花酸酯是通过CR水解法在SE胃肠道消化后产生的。本研究旨在探讨SE、CCT和CR对两种侵袭性PCa细胞系(PC3和22Rv1)在裸鼠体内移植瘤生长的影响。我们证明，CCT的抗肿瘤作用高于CR和SE，并且治疗逆转了上皮-间充质转分化(EMT)，其证据是N-钙粘素和β-连环素的表达显着降低，E-钙粘附素的表达增加。此外，SE、CR和CCT通过下调金属蛋白酶和尿激酶的表达/活性来抑制PCa细胞的侵袭和迁移，提示这些药物可能影响转移过程。我们的发现表明，CR和CCT可能是饮食中的植物化学物质，在具有生物侵袭性的PCa细胞中具有潜在的抗肿瘤作用。
Crocus sativus L. extracts (saffron) are rich in carotenoids. Preclinical studies have shown that dietary intake of carotenoids has antitumor effects suggesting their potential preventive and/or therapeutic roles. We have recently reported that saffron (SE) and crocin (CR) exhibit anticancer activity by promoting cell cycle arrest in prostate cancer (PCa) cells. It has also been demonstrated that crocetin esters are produced after SE gastrointestinal digestion by CR hydrolysis. The aim of the present report was to investigate if SE, crocetin (CCT), and CR affected in vivo tumor growth of two aggressive PCa cell lines (PC3 and 22rv1) which were xenografted in male nude mice treated by oral gavage with SE, CR, and CCT. We demonstrated that the antitumor effects of CCT were higher when compared to CR and SE and treatments reverted the epithelial-mesenchymal transdifferentiation (EMT) as attested by the significant reduction of N-cadherin and beta-catenin expression and the increased expression of E-cadherin. Additionally, SE, CR, and CCT inhibited PCa cell invasion and migration through the downmodulation of metalloproteinase and urokinase expression/activity suggesting that these agents may affect metastatic processes. Our findings suggest that CR and CCT may be dietary phytochemicals with potential antitumor effects in biologically aggressive PCa cells.
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影响因子：
2.7
作者：
Chryssanthi, Dimitra G.;Dedes, Petros G.;Lamari, Fotini N.
通讯作者：
Lamari, Fotini N.
影响因子：
3.3
作者：
Gao, Qing;Liu, Wei;Li, Zongfang
通讯作者：
Li, Zongfang
DOI：
10.1080/01635581.2013.767368
发表时间：
2013-08-01
影响因子：
2.9
作者：
D'Alessandro, Anna M.;Mancini, Andrea;Festuccia, Claudio
通讯作者：
Festuccia, Claudio
影响因子：
6.1
作者：
Carmona, M;Zalacain, A;Alonso, GL
通讯作者：
Alonso, GL
影响因子：
8.8
作者：
Cossignani, Lina;Urbani, Eleonora;Blasi, Francesca
通讯作者：
Blasi, Francesca