Cascade Electrophilic Iodocyclization: Efficient Preparation of 4-Iodomethyl Substituted Tetrahydro-β-carbolines and Formal Synthesis of Oxopropaline G
Cascade Electrophilic Iodocyclization: Efficient Preparation of 4-Iodomethyl Substituted Tetrahydro-β-carbolines and Formal Synthesis of Oxopropaline G
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DOI：
10.1021/ol401303f
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发表时间：
2013-07-05
期刊：
影响因子：
5.2
通讯作者：
Wang, Qingmin
中科院分区：
文献类型：
--
作者：
Song, Hongjian;Liu, Yongxian;Wang, Qingmin
4-碘甲基取代四氢-β-卡宾是许多天然产物和生物活性分子的核心结构，通过I-2促进的级联亲电环化反应很容易制备。烯烃和炔烃的反应性差异确保了反应的顺利进行。该方法成功地应用于氧丙氨酸G的合成。
4-Iodomethyl substituted tetrahydro-beta-carbolines, the core structure of numerous natural products and bioactive molecules, are readily prepared via I-2-promoted cascade electrophilic cyclization. The reactivity differences of olefins and alkynes ensure that the reaction proceeds smoothly. This methodology was successfully applied to the formal synthesis of oxopropaline G.