Stereospecific synthesis of (±)-1,2-anhydro methyl rocaglate
Stereospecific synthesis of (±)-1,2-anhydro methyl rocaglate
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DOI：
10.1021/ol0513793
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发表时间：
2005-09-01
期刊：
影响因子：
5.2
通讯作者：
Stent, MAH
中科院分区：
文献类型：
--
作者：
Magnus, P;Stent, MAH
由于其有效的抗肿瘤活性，罗卡酯及其类似物最近已成为合成的靶标。主要困难之一是控制相邻的-Ph和-An基团的立体化学。在这封信中，我们表明，14转化为5作为一个单一的立体异构体，并随后转化为1，2-脱水甲基rocaglate 20。
The rocaglates and analogues thereof have recently become targets for synthesis because of their potent antitumor activity. One of the major difficulties has been the control of stereochemistry of the adjacent -Ph and -An groups. In this letter we show that 14 is converted into 5 as a single stereoisomer and subsequently transformed into 1,2-anhydro methyl rocaglate 20.