HUMAN SATELLITE CELL-PROLIFERATION IN-VITRO IS REGULATED BY AUTOCRINE SECRETION OF IL-6 STIMULATED BY A SOLUBLE FACTOR(S) RELEASED BY ACTIVATED MONOCYTES
HUMAN SATELLITE CELL-PROLIFERATION IN-VITRO IS REGULATED BY AUTOCRINE SECRETION OF IL-6 STIMULATED BY A SOLUBLE FACTOR(S) RELEASED BY ACTIVATED MONOCYTES
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DOI：
10.1006/bbrc.1995.2590
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发表时间：
1995-11-02
影响因子：
3.1
通讯作者：
CARRARO, U
中科院分区：
文献类型：
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作者：
CANTINI, M;MASSIMINO, ML;CARRARO, U
我们以前的研究表明，巨噬细胞，除了他们的清道夫的作用，选择性地诱导大鼠成肌细胞增殖在体外释放可溶性因子。在本文中，我们证明了人类激活的单核细胞和增加人成肌细胞增殖由于IL-6自分泌分泌卫星细胞之间的关系。事实上，在用活化的单核细胞条件培养基处理的肌肉培养物的上清液中，我们通过ELISA定量显示了与成肌细胞增殖增加相关的IL-6的较高自分泌分泌。这表明活化的单核细胞分泌的生长因子刺激成肌细胞产生IL-6，然后调节卫星细胞的增殖。(C)出版社：Academic Press
We previously showed that macrophages, besides their scavenger role, selectively induce rat myoblast proliferation in vitro by releasing soluble factors. In this paper we demonstrate a relationship between human-activated monocytes and increased human myoblast proliferation due to IL-6 autocrine secretion by satellite cells. Indeed in the supernatants of muscle cultures treated with activated monocyte-conditioned medium we show by means of an ELISA quantitation a higher autocrine secretion of IL-6 associated with increased myoblast proliferation. This suggests that a growth factor(s) secreted by activated monocytes stimulates IL-6 production by myoblasts and then regulates proliferation of satellite cells. (C) 1995 Academic Press, Inc.