Histologic features predict local recurrence after breast conserving therapy of phyllodes tumors
Histologic features predict local recurrence after breast conserving therapy of phyllodes tumors
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DOI：
10.1023/a:1006260225618
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发表时间：
1999-10-01
影响因子：
3.8
通讯作者：
Barth, RJ
中科院分区：
文献类型：
--
作者：
Barth, RJ
背景资料：病理学家可以区分良性叶状肿瘤，很少转移，从恶性叶状肿瘤，转移在大约四分之一的患者。然而，这些相同的组织学标准是否可以用来预测叶状肿瘤在保乳治疗后局部复发的可能性仍然存在争议。研究设计：由于在任何一个单独的系列中，很少有恶性叶状肿瘤患者接受保乳手术治疗，因此使用Medline检索文献。乳腺良性、交界性和恶性叶状肿瘤局部切除后分别有21例（111/540）、46例（18/39）和65例（26/40）复发。乳腺良性、交界性和恶性叶状肿瘤行广泛局部切除术后，分别有8例（17/212）、29例（20/68）和36例（16/45）复发。交界性和恶性叶状肿瘤的局部复发率很高，这表明广泛的局部切除并不是最佳的治疗方法，并挑战我们寻找改善局部肿瘤控制的方法。
Background: Pathologists can distinguish benign phyllodes tumors, which very rarely metastasize, from malignant phyllodes tumors, which metastasize in approximately one fourth of patients. However, whether these same histologic criteria can be used to predict the likelihood that a phyllodes tumor will locally recur after breast conserving therapy remains controversial.Study Design: Since few patients with malignant phyllodes tumors have been treated with breast conserving surgery in any individual series, the literature was reviewed using a Medline search.Results: After local excision, 21 (111/540), 46 (18/39), and 65 (26/40) of patients with benign, borderline, and malignant phyllodes tumors, respectively, recurred in the breast. Following wide local excision, 8 (17/212), 29 (20/68), and 36 (16/45) of patients with benign, borderline, and malignant phyllodes tumors recurred in the breast.Conclusions: Malignant phyllodes tumors are much more likely than benign phyllodes tumors to recur in the breast after breast conserving surgery. This high rate of local recurrence of borderline and malignant phyllodes tumors suggests that wide local excision is less than optimal therapy, and challenges us to look for methods to improve local tumor control.