Plasma concentrations of parabens in postmenopausal women and self-reported use of personal care products: the NOWAC postgenome study
Plasma concentrations of parabens in postmenopausal women and self-reported use of personal care products: the NOWAC postgenome study
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DOI：
10.1038/jes.2011.22
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发表时间：
2011-11-01
影响因子：
4.5
通讯作者：
Lund, Eiliv
中科院分区：
文献类型：
--
作者：
Sandanger, Torkjel M.;Huber, Sandra;Lund, Eiliv
对羟基苯甲酸酯广泛用于个人护理产品；然而，它们的雌激素特性引起了人们对人类健康风险的担忧。据报道，人血浆/血清中含有高含量的总对羟基苯甲酸酯（主要为缀合物），而有关天然对羟基苯甲酸酯的数据有限。我们的目标是评估普通人群中天然常见对羟基苯甲酸酯的血浆浓度，并将其与自我报告的个人护理产品使用情况联系起来。这些信息是从 NOWAC 研究中的女性先前回答的有关饮食和生活方式的广泛调查问卷中获得的。通过自动固相萃取对 332 名个体的血浆样本进行提取和净化，并通过超高效液相色谱飞行时间质谱进行分析。天然对羟基苯甲酸甲酯占主导地位，在 63% 的样品中检测到，中位水平为 9.4 ng/ml。对羟基苯甲酸乙酯（中位
Parabens are used extensively in personal care products; however, their estrogenic properties have raised concern over risks to human health. High levels of total parabens, mainly as conjugates, have been reported in human plasma/serum, with limited data on native parabens. Our objective was to assess and link plasma concentrations of native common parabens to self-reported use of personal care products in women from the general population. The information was obtained from an extensive questionnaire on diet and lifestyle previously answered by the women in the NOWAC study. Plasma samples from 332 individuals were extracted and cleaned up by automated solid phase extraction and analyzed by ultra high performance liquid chromatography time-of-flight mass spectrometry. Native methyl paraben dominated and was detected in 63% of the samples, with a median level of 9.4 ng/ml. Ethyl paraben (median