MetPA: a web-based metabolomics tool for pathway analysis and visualization
MetPA: a web-based metabolomics tool for pathway analysis and visualization
复制标题
DOI：
10.1093/bioinformatics/btq418
复制
发表时间：
2010-09-01
期刊：
影响因子：
5.8
通讯作者：
Wishart, David S.
中科院分区：
文献类型：
--
作者：
Xia, Jianguo;Wishart, David S.
MetPA（代谢组学途径分析）是一个用户友好的、基于网络的工具，致力于在代谢途径的生物学背景下分析和可视化代谢组学数据。MetPA结合了几种先进的途径富集分析程序以及途径拓扑特征分析，以帮助确定给定代谢组学研究中涉及的最相关的代谢途径。结果显示在一个谷歌地图风格的网络可视化系统中，该系统支持通过点击、拖动和无损缩放来进行直观和交互式的数据探索。其他功能包括用于代谢物名称转换的综合化合物库，自动生成分析报告，以及当用户单击路径图上的任何代谢物节点时可以访问的各种单变量统计程序的实现。MetPA目前能够分析和可视化874种代谢途径，涵盖11种常见的模式生物。
MetPA (Metabolomics Pathway Analysis) is a userfriendly, web-based tool dedicated to the analysis and visualization of metabolomic data within the biological context of metabolic pathways. MetPA combines several advanced pathway enrichment analysis procedures along with the analysis of pathway topological characteristics to help identify the most relevant metabolic pathways involved in a given metabolomic study. The results are presented in a Google-map style network visualization system that supports intuitive and interactive data exploration through point-and-click, dragging and lossless zooming. Additional features include a comprehensive compound library for metabolite name conversion, automatic generation of analysis report, as well as the implementation of various univariate statistical procedures that can be accessed when users click on any metabolite node on a pathway map. MetPA currently enables analysis and visualization of 874 metabolic pathways, covering 11 common model organisms.