Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants
Mechanisms by which maternal antibodies influence infant vaccine responses: review of hypotheses and definition of main determinants
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DOI：
10.1016/s0264-410x(03)00342-6
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发表时间：
2003-07-28
期刊：
影响因子：
5.5
通讯作者：
Siegrist, CA
中科院分区：
文献类型：
--
作者：
Siegrist, CA
已有几种机制被认为是调节母体抗体(Matab)对婴儿反应的抑制影响。这种抑制是B细胞决定簇特异性的，取决于免疫时Matab滴度与疫苗抗原剂量之间的比率，使婴儿的T细胞反应基本上不受影响。中和疫苗复制或FcGammaRIIB介导的对婴儿B细胞的抑制信号不会解释这些特征。相比之下，对B细胞表位的决定簇特异性掩蔽和对Matab：疫苗抗原免疫复合物的APC吸收，随后进行抗原处理和呈递，解释了临床前和临床对婴儿疫苗的反应模式。这使得能够定义Matab对婴儿免疫的影响的主要决定因素。(C)2003爱思唯尔科学有限公司。保留所有权利。
Several mechanisms have been suggested as mediating the inhibitory influence of maternal antibodies (MatAb) on infant responses. This inhibition is B cell determinant-specific, depends on the ratio between MatAb titers at the time of immunization and the dose of vaccine antigen, and leaves infant T cell responses largely unaffected. Neutralization of vaccine replication or FcgammaRIIB-mediated inhibitory signalling to infant B cells would not account for these characteristics. In contrast, determinant-specific masking of B cell epitopes and APC uptake of MatAb:vaccine antigen immune complexes, followed by antigen processing and presentation, explain the pattern of pre-clinical and clinical responses to infant vaccines. This allows the definition of the main determinants of the influence of MatAb on infant immunity. (C) 2003 Elsevier Science Ltd. All rights reserved.