Primary cutaneous diffuse large B cell lymphoma-other successfully treated by the combination of R-CHOP chemotherapy and surgery: A case report and review of literature.
Primary cutaneous diffuse large B cell lymphoma-other successfully treated by the combination of R-CHOP chemotherapy and surgery: A case report and review of literature.
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原发性皮肤弥漫性大B细胞淋巴瘤 - 另一个通过R-Chop化学疗法和手术的结合成功治疗的：病例报告和文献综述。
DOI：
10.1097/md.0000000000006161
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发表时间：
2017-03
期刊：
影响因子：
1.6
通讯作者：
Zheng Y
中科院分区：
文献类型：
--
作者：
Jia J;Li W;Zheng Y
原发性皮肤弥漫性大B细胞淋巴瘤-其他（PCDLBCL-O）的发生在文献中很少报道。其诊断依据是组织病理学和免疫组化检查。为提高PCDLBCL-0的临床诊断和治疗水平，我们报告1例PCDLBCL-0患者，采用R-CHOP方案（环磷酰胺、阿霉素、长春新碱、泼尼松+利妥昔单抗）化疗和手术治疗，取得了较好的疗效。分析该病例的临床表现、病理特征、治疗及预后。患者为56岁女性，左乳房出现红色斑块和结节6个月。根据临床表现、组织病理学和免疫组化结果，患者被诊断为PCDLBCL-O。患者接受了6个疗程的R-CHOP化疗联合手术切除治疗。本组病例经3年随访无复发，疗效较好。原发性皮肤弥漫性大B细胞淋巴瘤通常发生在腿部（腿部型），很少发生在身体的其他部位。其临床表现多样，诊断依赖于组织病理学和免疫组化检查。与全身弥漫性大B细胞淋巴瘤一样，患者应接受全身化疗。
The occurrence of primary cutaneous diffuse large B cell lymphoma-other (PCDLBCL-O) has been rarely reported in the literature. Its diagnosis is based on histopathological and immunohistochemical examinations. To improve the clinical diagnosis and treatment for PCDLBCL-O, we report a case of PCDLBCL-O successfully treated by the combination of R-CHOP (A chemotherapy protocol consists of cyclophosphamide, doxorubicin, vincristine, prednisone plus Rituximab) chemotherapy and surgery. The clinical manifestations, pathological characteristics, treatment and prognosis of the case were analyzed. The patient was a 56-year-old female, presenting with red plaques and nodules in her left breast for 6 months. Based on the clinical manifestation, histopathological and immunohistochemical results, the patient was diagnosed with PCDLBCL-O. She was treated with 6 courses of R-CHOP chemotherapy combined with surgical resection. In the present case, fairly good curative effect was appeared with no recurrence within the 3 years’ follow-up. Primary cutaneous diffuse large B cell lymphoma commonly occurs on the legs (leg type), rarely on other sites of the body. The clinical manefestations are so variant that its diagnosis depends on histopathological and immunohistochemical examinations. Like systemic diffuse large B cell lymphoma, patients should be treated with systemic chemotherapy.