Drug-Induced Hypersensitivity Syndrome Associated with Transient Hypogammaglobulinaemia and Increase in Serum IgE Level
Drug-Induced Hypersensitivity Syndrome Associated with Transient Hypogammaglobulinaemia and Increase in Serum IgE Level
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与暂时性低丙种球蛋白血症和血清 IgE 水平升高相关的药物引起的过敏综合征
DOI：
10.1159/000084765
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发表时间：
2005
期刊：
影响因子：
3.4
通讯作者：
Kunihiko Tamaki
中科院分区：
文献类型：
--
作者：
H. Nakashima;K. Yamane;H. Ihn;Kouki Nakamura;Rei Watanabe;Y. Kuwano;T. Takekoshi;Takahiro Watanabe;Naoko Hattori;Manabu Fujimoto;Kunihiko Tamaki
药物性超敏反应综合征（DIHS）是一种罕见但严重的多器官功能衰竭疾病。最近，人类疱疹病毒（HHV）家族，特别是HHV-6，与DIHS的关联已被报道。我们报告一位43岁女性，根据临床病程及实验室检查诊断为DIHS。HHV-6再活化表现为配对血清中特异性抗体水平显著升高和HHV-6 DNA聚合酶链反应。值得注意的是，在疾病早期检测到一过性低丙种球蛋白血症，这与疾病活动相关。与此相反，血清IgE水平和嗜酸性粒细胞增加2或3周后。此外，血清干扰素γ、白细胞介素（IL）-4和可溶性IL-2受体水平在发病早期升高，激素治疗后逐渐下降。
Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe disease with multiorgan failure. Recently, the association of the human herpesvirus (HHV) family, particularly of HHV-6, with DIHS has been reported. We report a 43-year-old female diagnosed as having DIHS based on the clinical course and laboratory examinations. The HHV-6 reactivation was demonstrated by significantly increased levels of the specific antibody in her paired sera and by polymerase chain reaction of HHV-6 DNA. Notably, transient hypogammaglobulinaemia was detected in the early stage of the disease, which was associated with the disease activity. By contrast, the serum IgE level and eosinophils were increased 2 or 3 weeks later. In addition, serum levels of interferon γ, interleukin (IL)-4 and soluble IL-2 receptor, which were increased in the early phase of the disease, decreased gradually after the corticosteroid therapy.