CHEMOPREVENTIVE ACTION OF GARLIC ON METHYLCHOLANTHRENE-INDUCED CARCINOGENESIS IN THE UTERINE CERVIX OF MICE
CHEMOPREVENTIVE ACTION OF GARLIC ON METHYLCHOLANTHRENE-INDUCED CARCINOGENESIS IN THE UTERINE CERVIX OF MICE
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DOI：
10.1016/0304-3835(90)90155-q
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发表时间：
1990-02-01
期刊：
影响因子：
9.7
通讯作者：
RAO, AR
中科院分区：
文献类型：
--
作者：
HUSSAIN, SP;JANNU, LN;RAO, AR
本文报道了大蒜对3-甲基胆蒽(MCA)诱导的未成年瑞士白化小鼠宫颈癌变的化学预防作用。将浸渍有约600微克MCA的蜂蜡的无菌棉线插入宫颈管内，会导致宫颈上皮出现癌前病变和癌变。在这个实验性的宫颈癌变模型系统中，大蒜按400 mg/kg体重/天的剂量水平，在插入致癌剂丝线前2周和之后4周灌胃。宫颈癌发病率为23%，高于阳性对照组(73%)。癌症发病率的下降非常显著(P<；0.01)。增生性和非增殖性改变与大蒜处理无明显相关性。
The present paper reports the chemopreventive action of garlic on 3-methylcholanthrene (MCA)-induced carcinogenesis in the uterine cervix of virgin young adult Swiss albino mice. Insertion of sterile cotton thread impregnated with beeswax containing .apprx.600 .mu.g of MCA inside the canal of uterine cervix results in the appearance of precancerous and cancerous lesions in the cervical epithelium. In this experimental cervical carcinogensis model system, if garlic was administered orally at the dose level of 400 mg/kg body wt./day for 2 weeks before and 4 weeks following carcinogen thread insertion. The cervical carcinoma incidence, as compared with that of the positive control (73%), was 23%. This decline in the incidence of carcinoma was highly significant (P < 0.01). Hyperplastic and dysplastic changes did not show any definite correlation with the garlic treatment.