Incidence of and Risk Factors for Systemic Adverse Events After Screening or Primary Diagnostic Colonoscopy: A Nationwide Cohort Study
Incidence of and Risk Factors for Systemic Adverse Events After Screening or Primary Diagnostic Colonoscopy: A Nationwide Cohort Study
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DOI：
10.14309/ajg.0000000000000574
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发表时间：
2020-04-01
影响因子：
9.8
通讯作者：
Coste, Joel
中科院分区：
文献类型：
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作者：
Laanani, Moussa;Weill, Alain;Coste, Joel
目的：估计结肠镜检查后全身严重不良事件（SAE）发生率并确定其危险因素。方法：使用法国综合索赔数据库 SNDS（国家健康数据系统）进行了一项全国性队列研究。纳入对象为 2010-2015 年接受首次筛查或诊断性结肠镜检查的 30 岁及以上患者。结肠镜检查后 5 天内评估心血管和肾脏 SAE 的发生率。计算标准化发病率，将这些发病率与一般人群中相同事件的发病率进行比较，并通过多级逻辑回归评估相关危险因素。结果：在 4,088,799 名患者中（中位年龄 59 岁 [四分位数范围 = 50-67]；55.2% 为女性；30.1% 有 Charlson 指数评分）
OBJECTIVES: To estimate the systemic serious adverse event (SAE) rates after colonoscopy and to identify their risk factors. METHODS: A nationwide cohort study was conducted using the comprehensive French claims databases SNDS (National Health Data System). Patients aged 30 years and over who underwent a first screening or diagnostic colonoscopy in 2010-2015 were included. The rates of cardiovascular and renal SAEs were estimated within 5 days after colonoscopy. The standardized incidence ratios were calculated to compare these incidence rates with those of the same events in the general population, and the associated risk factors were assessed by multilevel logistic regression. RESULTS: Among the 4,088,799 included patients (median age, 59 years [interquartile range = 50-67]; 55.2% women; 30.1% with a Charlson index score