Activation of microbubbles by low-intensity pulsed ultrasound enhances the cytotoxicity of curcumin involving apoptosis induction and cell motility inhibition in human breast cancer MDA-MB-231 cells
Activation of microbubbles by low-intensity pulsed ultrasound enhances the cytotoxicity of curcumin involving apoptosis induction and cell motility inhibition in human breast cancer MDA-MB-231 cells
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DOI：
10.1016/j.ultsonch.2016.04.012
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发表时间：
2016-11-01
影响因子：
8.4
通讯作者：
Liu, Quanhong
中科院分区：
文献类型：
--
作者：
Li, Yixiang;Wang, Pan;Liu, Quanhong
超声和微泡介导的药物传递已成为一种很有前途的策略，以促进药物的传递和治疗效果。本研究的目的是评估微泡（MBs）结合低强度脉冲超声（LPUS）对姜黄素（Cur）的递送和对人乳腺癌MDA-MB-231细胞的细胞毒性的影响。在本实验条件下，MBs可提高声空化水平，增强细胞膜通透性; LPUS-MBs可显著提高细胞对Cur的摄取，加重Cur诱导的MDA-MB-231细胞死亡。联合用药组细胞形态学改变、F-actin细胞骨架损伤及细胞迁移抑制更为明显。我们的研究结果表明，MBs和LPUS的组合可能是一个有效的策略，以提高Cur的抗肿瘤作用，提示一个潜在的有效的方法，肿瘤治疗。(C)© 2016 Elsevier B. V.版权所有。
Ultrasound and microbubbles-mediated drug delivery has become a promising strategy to promote drug delivery and its therapeutic efficacy. The aim of this research was to assess the effects of microbubbles (MBs)-combined low-intensity pulsed ultrasound (LPUS) on the delivery and cytotoxicity of curcumin (Cur) to human breast cancer MDA-MB-231 cells. Under the experimental condition, MBs raised the level of acoustic cavitation and enhanced plasma membrane permeability; and cellular uptake of Cur was notably improved by LPUS-MBs treatment, aggravating Cur-induced MDA-MB-231 cells death. The combined treatment markedly caused more obvious changes of cell morphology, F-actin cytoskeleton damage and cell migration inhibition. Our results demonstrated that combination of MBs and LPUS may be an efficient strategy for improving anti-tumor effect of Cur, suggesting a potential effective method for antineoplastic therapy. (C) 2016 Elsevier B.V. All rights reserved.