Imbalance of helper T cell type 1, helper T cell type 2 and associated cytokines in patients with systemic lupus erythematosus: A meta-analysis.
Imbalance of helper T cell type 1, helper T cell type 2 and associated cytokines in patients with systemic lupus erythematosus: A meta-analysis.
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DOI：
10.3389/fphar.2022.988512
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
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目的：Th 1和Th 2细胞及其相关细胞因子在系统性红斑狼疮（SLE）的发病机制中发挥作用，但其确切作用尚不清楚。我们进行了荟萃分析，以检查这些细胞和细胞因子与SLE的关系。 研究方法：检索多个数据库，以确定报告SLE患者和健康对照（HC）中Th 1和Th 2细胞及其相关细胞因子百分比的出版物。使用Stata MP版本16进行荟萃分析。 结果如下：SLE患者的Th 1细胞百分比较低，Th 2细胞百分比较高，Th 1和Th 2相关细胞因子水平高于HC。SLE治疗使部分但非全部指标正常化。在女性比例低于94%的研究中，患者的Th 2细胞百分比和IL-10水平高于HC。肾功能异常且年龄小于30岁的SLE患者Th 1细胞比例高于HC。30岁以上SLE患者IL-6水平高于HC。 结论：药物治疗可恢复SLE患者Th 1细胞及其他疾病指标的平衡。性别和年龄影响Th 1和Th 2细胞的水平，Th 2细胞水平异常升高似乎在老年患者和男性中更为明显。 系统性综述注册：[https：//www.crd.york.ac.uk/pagio/]，标识符[CRD 42022296540]。
Objective: Th1 and Th2 cells and their associated cytokines function in the pathogenesis of systemic lupus erythematosus (SLE), but their exact roles are uncertain. We performed a meta-analysis to examine the relationship of these cells and cytokines with SLE. Methods: Multiple databases were searched to identify publications that reported the percentages of Th1 and Th2 cells and their associated cytokines in SLE patients and healthy controls (HCs). Meta-analysis was performed using Stata MP version 16. Results: SLE patients had a lower percentage of Th1 cells, a higher percentage of Th2 cells, and higher levels of Th1- and Th2-associated cytokines than HCs. SLE treatments normalized some but not all of these indicators. For studies in which the proportion of females was less than 94%, the percentage of Th2 cells and the level of IL-10 were higher in patients than HCs. SLE patients who had abnormal kidney function and were younger than 30 years old had a higher proportion of Th1 cells than HCs. SLE patients more than 30 years old had a higher level of IL-6 than HCs. Conclusion: Medications appeared to restore the balance of Th1 cells and other disease indicators in patients with SLE. Gender and age affected the levels of Th1 and Th2 cells, and the abnormally elevated levels of Th2 cells appear to be more pronounced in older patients and males. Systematic Review Registration: [https://www.crd.york.ac.uk/prospero/], identifier [CRD42022296540].
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影响因子：
7.3
作者：
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影响因子：
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作者：
Brunner, Hermine I.;Gladman, Dafna D.;Silverman, Earl D.
通讯作者：
Silverman, Earl D.
影响因子：
4.7
作者：
Hayashino Y;Noguchi Y;Fukui T
通讯作者：
Fukui T
影响因子：
16.6
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Dufour A;Bellac CL;Eckhard U;Solis N;Klein T;Kappelhoff R;Fortelny N;Jobin P;Rozmus J;Mark J;Pavlidis P;Dive V;Barbour SJ;Overall CM
通讯作者：
Overall CM
影响因子：
82.9
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