Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis
Anti-dsDNA, anti-Sm antibodies, and the lupus anticoagulant: significant factors associated with lupus nephritis
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DOI：
10.1136/ard.62.6.556
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发表时间：
2003-06-01
影响因子：
27.4
通讯作者：
Hughes, GRV
中科院分区：
文献类型：
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作者：
Alba, P;Bento, L;Hughes, GRV
背景：狼疮性肾炎（LN）是系统性红斑狼疮（SLE）患者的常见表现。自身抗体和种族已与LN，但结果是有争议的。目的：研究免疫学和人口统计学因素与LN的发展。患者和方法：一个回顾性病例对照研究127例活检证实LN，206例随机选择的SLE无肾炎作为对照。在过去的12年里，所有患者都参加了我们的狼疮单位。结果：LN患者在SLE诊断时明显年轻于对照组（平均（SD）25.6（8.8）岁vs33.7（12.5）岁; P
Background: Lupus nephritis (LN) is a common manifestation in patients with systemic lupus erythematosus (SLE). Autoantibodies and ethnicity have been associated with LN, but the results are controversial.Objective: To study the immunological and demographic factors associated with the development of LN.Patients and methods: A retrospective case-control study of 127 patients with biopsy-proven LN, and 206 randomly selected patients with SLE without nephritis as controls was designed. All patients had attended our lupus unit during the past 12 years. Standard methods were used for laboratory testing.Results: Patients with LN were significantly younger than the controls at the time of SLE diagnosis (mean (SD) 25.6 (8.8) years v 33.7 (12.5) years; p