RESPIRATORY SYNCYTIAL VIRUS ACUTE RESPIRATORY INFECTIONS IN ≥65-YEAR-OLD ADULTS IN LONG-TERM CARE FACILITIES IN THE CZECH REPUBLIC
RESPIRATORY SYNCYTIAL VIRUS ACUTE RESPIRATORY INFECTIONS IN ≥65-YEAR-OLD ADULTS IN LONG-TERM CARE FACILITIES IN THE CZECH REPUBLIC
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DOI：
10.21101/cejph.a6861
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发表时间：
2021-01-01
影响因子：
1.2
通讯作者：
Devaster, Jeanne-Marie
中科院分区：
文献类型：
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作者：
Beran, Jiri;Villaescusa, Ana Ramirez;Devaster, Jeanne-Marie
目的：由于免疫衰老和合并症的存在，呼吸道合胞病毒（RSV）疾病负担是老年人的主要健康问题，预计随着预期寿命的增加而增加。在长期护理机构居住的老年人中，RSV负担的数据很少，这是一个生活在拥挤环境中的脆弱人群。因此，在2003-2004年和2004-2005年RSV季节期间进行了两项独立的前瞻性研究，以评估居住在捷克共和国长期护理机构的≥ 65岁成年人中的RSV急性呼吸道疾病（阿里斯）和下呼吸道感染（LRTI）。在症状发作后3天内采集鼻拭子，通过聚合酶链反应证实RSV ARI发作。评估了RSV确认的阿里斯的死亡率和发病率，以及与RSV确认的阿里斯相关的风险因素。结果：在2003-2004年季节（10月至3月期间的ARI监测）的1，251名参与者中，255例ARI和105例LRTI发作中没有RSV阳性病例。在2004-2005年季节（10月至4月期间的ARI监测）的1,280名参与者中，335例ARI和217例LRTI发作中分别有39例和26例RSV阳性病例，RSV阳性ARI和LRTI发作发生率分别为45.82/1000人-年和30.40/1000人-年。在2004-2005年季节的290例RSV阴性和39例RSV阳性ARI病例中，报告了15例和4例住院，188例和26例LRTI，11例和3例死亡。与RSV阳性ARI相关的危险因素是女性（优势比：4.98），慢性心力衰竭II级（优势比：2.31）和糖尿病需要胰岛素治疗（优势比：9.82）。结论：这些研究表明，RSV是一个重要的原因，ARI的老年人生活在长期护理设施在2004-2005赛季，每年波动的发病率。
Objectives: Due to immunosenescence and presence of comorbidities, respiratory syncytial virus (RSV) disease burden is a major health concern in older adults, which is expected to increase with the life expectancy rise. Data on RSV burden are scarce in older adults residing in long-term care facilities, a vulnerable population living in crowded settings. Therefore, two independent prospective studies were conducted during the 2003-2004 and 2004-2005 RSV seasons to assess RSV acute respiratory illnesses (ARIs) and lower respiratory tract infections (LRTIs) in >= 65-year-old adults residing in long-term care facilities in the Czech Republic.Methods: RSV ARI episodes were confirmed by polymerase chain reaction in nasal swabs collected within 3 days of symptoms onset. The mortality and morbidity of RSV-confirmed ARIs, as well as the risk factors associated with RSV-confirmed ARIs were evaluated.Results: Among 1,251 participants in the 2003-2004 season (ARI surveillance between October and March), there were no RSV-positive cases in 255 ARI and 105 LRTI episodes. Among 1,280 participants in the 2004-2005 season (ARI surveillance between October and April), there were 39 and 26 RSV-positive cases in 335 ARI and 217 LRTI episodes, respectively, and RSV-positive ARI and LRTI episode incidence rates were 45.82 and 30.40 per 1,000 person-years. Among 290 RSV-negative and 39 RSV-positive ARI cases in the 2004-2005 season, 15 and 4 hospitalizations, 188 and 26 LRTIs, and 11 and 3 deaths were reported. Risk factors associated with RSV-positive ARI were female gender (odds ratio: 4.98), chronic heart failure class II (odds ratio: 2.31) and diabetes requiring insulin treatment (odds ratio: 9.82).Conclusions: These studies showed that RSV was an important cause of ARI in older adults living in long-term care facilities in the 2004-2005 season, with fluctuating yearly incidences.