Ion-release kinetics and ecotoxicity effects of silver nanoparticles
Ion-release kinetics and ecotoxicity effects of silver nanoparticles
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DOI：
10.1002/etc.717
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发表时间：
2012-01-01
影响因子：
4.1
通讯作者：
Kim, Sang-Ho
中科院分区：
文献类型：
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作者：
Lee, Yong-Ju;Kim, Jiwon;Kim, Sang-Ho
银纳米颗粒(AgNPs)的环境毒性一直是纳米毒理学研究的热点。AgNPs释放的Ag+可能会影响生态毒性，但主要的毒性效应是由Ag+离子还是由AgNPs本身控制尚不清楚。在本研究中，我们研究了AgNPs对水生生物的生态毒性、AgNPs的银离子释放动力学以及它们之间的关系。粉末型AgNP悬浮液对大型水蚤48h半数有效浓度(EC50值)为0.75mUg/L(95%可信区间=0.710.78)，总银0.37mg/L(95%CI=0.360.38)。对于溶胶型AgNP混悬液，48 h的EC50值为7.98mU/L(95%CI=7.049.03)总银和0.88mU/L(95%CI=0.800.97)溶解银。粉末型和溶胶型AgNPs的EC50值与粉末型和溶胶型AgNPs的EC50值相近，分别为0.37mUg/L和0.88mg/L，尽管它们在总银中的EC50值不同。我们观察到，在22℃下6h内，当总银浓度为0.05 mg/L时，银纳米粒子释放出的银离子的一级速率常数(K)为0.0734/h。动力学实验和毒性实验表明，在氧化条件下，分别有36%和11%的溶胶型AgNPs转化为Ag+离子形式。粉末型AgNPs对AgNPs中Ag+离子的转化率为49%。我们还证实了AgNP悬浮液中的Ag+离子浓度在48h后达到平衡浓度，这是急性水毒性试验的暴露时间。环境。托昔康。化学。2012年；31：155159。(C)2011年SETAC
The environmental toxicity associated with silver nanoparticles (AgNPs) has been a major focus in nanotoxicology. The Ag+ released from AgNPs may affect ecotoxicity, although whether the major toxic effect is governed by Ag+ ions or by AgNPs themselves is unclear. In the present study, we have examined the ecotoxicity of AgNPs in aquatic organisms, silver ion-release kinetics of AgNPs, and their relationship. The 48-h median effective concentration (EC50) values for Daphnia magna of powder-type AgNP suspensions were 0.75 mu g/L (95% confidence interval [CI]=0.710.78) total Ag and 0.37 mu g/L (95% CI=0.360.38) dissolved Ag. For sol-type AgNP suspension, the 48-h EC50 values for D. magna were 7.98 mu g/L (95% CI=7.049.03) total Ag and 0.88 mu g/L (95% CI=0.800.97) dissolved Ag. The EC50 values for the dissolved Ag of powder-type and sol-type AgNPs for D. magna showed similar results (0.37 mu g/L and 0.88 mu g/L) despite their differences of EC50 values in total Ag. We observed that the first-order rate constant (k) of Ag+ ions released from AgNPs was 0.0734/h at 0.05mg/L total Ag at 22 degrees C within 6h. The kinetic experiments and the toxicity test showed that 36% and 11% of sol-type AgNPs were converted to the Ag+ ion form under oxidation conditions, respectively. Powder-type AgNPs showed 49% conversion rate of Ag+ ion from AgNPs. We also confirmed that Ag+ ion concentration in AgNP suspension reaches an equilibrium concentration after 48h, which is an exposure time of the acute aquatic toxicity test. Environ. Toxicol. Chem. 2012;31:155159. (C) 2011 SETAC