Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen.
Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen.
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尽管之前使用重组包膜疫苗方案进行了免疫接种，但仍感染 1 型人类免疫缺陷病毒。
DOI：
10.1073/pnas.93.9.3972
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发表时间：
1996
影响因子：
11.1
通讯作者：
Mullins,JI
中科院分区：
文献类型：
--
作者：
McElrath,MJ;Corey,L;Greenberg,PD;Matthews,TJ;Montefiori,DC;Rowen,L;Hood,L;Mullins,JI
随着预防性人类免疫缺陷病毒1型（HIV-1）疫苗的开发，目前尚不清楚哪种免疫反应足以防止感染，以及先前的HIV-1免疫是否可以改变随后的HIV-1感染过程。我们在一名志愿者的背景下调查了这些问题，他接受了六次HIV-1LAI包膜免疫接种，并在10周后通过高风险的性接触感染了HIV-1。与未接种疫苗的急性感染个体相比，该个体在3周内出现了遗忘性hiv -1特异性B细胞和t细胞反应，中和抗体先于CD8+细胞毒性反应。尽管病程无症状且最初可检测到的感染病毒水平较低，但在2年内出现了进行性CD4+细胞下降和功能障碍。虽然疫苗接种可引起对HIV-1包膜的免疫，但它不足以预防感染和随后的免疫缺陷。
With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether prior HIV-1 immunity can alter the subsequent course of HIV-1 infection. We investigated these issues in the context of a volunteer who received six HIV-1LAI envelope immunizations and 10 weeks thereafter acquired HIV-1 infection through a high-risk sexual exposure. In contrast to nonvaccinated acutely infected individuals, anamnestic HIV-1-specific B- and T-cell responses appeared within 3 weeks in this individual, and neutralizing antibody preceded CD8+ cytotoxic responses. Despite an asymptomatic course and an initial low level of detectable infectious virus, a progressive CD4+ cell decline and dysfunction occurred within 2 years. Although vaccination elicited immunity to HIV-1 envelope, which was recalled upon HIV-1 exposure, it was insufficient to prevent infection and subsequent immunodeficiency.