Circulating levels of insulin-like growth factor binding protein-1 in relation to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome (Chennai Urban Rural Epidemiology Study 118)
Circulating levels of insulin-like growth factor binding protein-1 in relation to insulin resistance, type 2 diabetes mellitus, and metabolic syndrome (Chennai Urban Rural Epidemiology Study 118)
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DOI：
10.1016/j.metabol.2011.05.014
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发表时间：
2012-01-01
影响因子：
9.8
通讯作者：
Mohan, Viswanathan
中科院分区：
文献类型：
--
作者：
Gokulakrishnan, Kuppan;Velmurugan, Kaliyaperumal;Mohan, Viswanathan
目的是评估亚洲印度人胰岛素样生长因子结合蛋白-1（IGFBP-1）与胰岛素抵抗（IR）、2型糖尿病（T2 DM）和代谢综合征（MS）的相关性。从Chennai城乡流行病学研究中随机选择50例糖耐量正常（NGT）和50例T2 DM受试者。胰岛素样生长因子结合蛋白-1测定采用夹心酶联免疫吸附法。使用Dako（Glostrup，丹麦）试剂盒估计血清胰岛素。使用稳态模型评估计算胰岛素抵抗。与NGT受试者（34.4 +/- 7.6 ng/mL，P <0.001）相比，T2 DM受试者的IGFBP-1水平显著降低（21.7 +/- 3.5 ng/mL）。通过稳态模型评估，IGFBP-1在有IR的NGT受试者中显著低于无IR的NGT受试者（25.5 +/- 6.5 ng/mL）（40.7 +/- 9.5 ng/mL，P < .001）。回归分析显示，即使在调整了年龄、性别、体重指数和糖化血红蛋白后，IR仍与IGFBP-1显著相关（β =-3.714，P < .001）。2型糖尿病与IGFBP-1显著相关，即使在调整了年龄、性别和体重指数后也是如此（β =-12.798，P < .001）。IGFBP-1水平随着代谢异常数量的增加而降低（趋势P < .001）。Logistic回归分析显示IGFBP-1与MS有很强的负相关性，即使在调整了年龄和性别后（比值比，0.942; 95%可信区间，0.914-0.971; P <0.001）。在亚洲印度人中，IR、T2 DM和MS受试者的循环IGFBP-1水平较低。（C）2012 Elsevier Inc. All rights reserved.
The objective was to assess the association of insulin-like growth factor binding protein-1 (IGFBP-1) with insulin resistance (IR), type 2 diabetes mellitus (T2DM), and metabolic syndrome (MS) in Asian Indians. Fifty subjects with normal glucose tolerance (NGT) and 50 with T2DM were randomly selected from the Chennai Urban Rural Epidemiology Study. Insulin-like growth factor binding protein-1 was measured by sandwich enzyme-linked immunosorbent assay. Serum insulin was estimated using Dako (Glostrup, Denmark) kits. Insulin resistance was calculated using the homeostasis model assessment. Subjects with T2DM had significantly decreased levels of IGFBP-1 (21.7 +/- 3.5 ng/mL) compared with NGT subjects (34.4 +/- 7.6 ng/mL, P < .001). The IGFBP-1 was significantly lower in NGT subjects with IR as measured by the homeostasis model assessment (25.5 +/- 6.5 ng/mL) compared with NGT subjects without IR (40.7 +/- 9.5 ng/mL, P < .001). On regression analysis, IR showed a significant association with IGFBP-1 even after adjusting for age, sex, body mass index, and glycated hemoglobin (beta = -3.714, P < .001). Type 2 diabetes mellitus was significantly associated with IGFBP-1 even after adjusting for age, sex, and body mass index (beta = -12.798, P < .001). The IGFBP-1 levels decreased with increasing number of metabolic abnormalities (P for trend < .001). Logistic regression analysis showed that IGFBP-1 had a strong negative association with MS even after adjusting for age and sex (odds ratio, 0.942; 95% confidence interval, 0.914-0.971; P < .001). Among Asian Indians, lower levels of circulating IGFBP-1 are seen in subjects with IR, T2DM, and MS. (C) 2012 Elsevier Inc. All rights reserved.