Advances in HBV infection and replication systems in vitro.
Advances in HBV infection and replication systems in vitro.
复制标题
乙肝病毒感染和复制系统的体外研究进展。
DOI：
10.1186/s12985-021-01580-6
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发表时间：
2021-05-29
期刊：
影响因子：
4.8
通讯作者：
Zhu C
中科院分区：
文献类型：
--
作者：
Xu R;Hu P;Li Y;Tian A;Li J;Zhu C
Hepatitis B virus (HBV) is a DNA virus belonging to the Hepadnaviridae family that has limited tissue and species specificity. Due to the persistence of HBV covalently closed circular DNA (cccDNA) in host cells after HBV infection, current antiviral drugs cannot eradicate HBV. Therefore, the development of an active cell culture system supporting HBV infection has become the key to studying HBV and developing effective therapeutic drugs. This review summarizes the significant research achievements in HBV cell culture systems in vitro, including embryonic hepatocytes and primary hepatocytes, which support the virus infection process most similar to that in the body and various liver tumor cells. The discovery of the bile-acid pump sodium-taurocholate co-transporting polypeptide (NTCP) as the receptor of HBV has advanced our understanding of HBV biology. Subsequently, various liver cancer cells overexpressing NTCP that support HBV infection have been established, opening a new door for studying HBV infection. The fact that induced pluripotent stem cells that differentiate into hepatocyte-like cells support HBV infection provides a novel idea for the establishment of an HBV cell culture system. Because of the host and tissue specificity of HBV, a suitable in vitro HBV infection system is critical for the study of HBV pathogenesis. Nevertheless, recent advances regarding HBV infection in vitro offer hope for better studying the biological characteristics of HBV, the pathogenesis of hepatitis B, the screening of anti-HBV drugs and the mechanism of carcinogenesis.
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影响因子：
7.6
作者：
Cai, Dawei;Wang, Xiaohe;Yan, Ran;Mao, Richeng;Liu, Yuanjie;Ji, Changhua;Cuconati, Andrea;Guo, Haitao
通讯作者：
Guo, Haitao
人肝细胞来源的肝祖样细胞的扩增和分化及其在嗜肝病原体研究中的应用
影响因子：
44.1
作者：
Fu GB;Huang WJ;Zeng M;Zhou X;Wu HP;Liu CC;Wu H;Weng J;Zhang HD;Cai YC;Ashton C;Ding M;Tang D;Zhang BH;Gao Y;Yu WF;Zhai B;He ZY;Wang HY;Yan HX
通讯作者：
Yan HX
影响因子：
13.5
作者：
Engelke, M;Mills, K;Urban, S
通讯作者：
Urban, S
影响因子：
5.4
作者：
GRIPON, P;DIOT, C;GUGUENGUILLOUZO, C
通讯作者：
GUGUENGUILLOUZO, C
影响因子：
5.4
作者：
Abdelhamed, AM;Kelley, CM;Isom, HC
通讯作者：
Isom, HC