The role of the biofilm matrix in structural development
The role of the biofilm matrix in structural development
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DOI：
10.1093/imammb21.2.147
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发表时间：
2004-06-01
影响因子：
1.1
通讯作者：
Keener, JP
中科院分区：
文献类型：
--
作者：
Cogan, NG;Keener, JP
尽管生物膜的引发、发展和控制已经成为实验研究领域三十多年，但细胞外聚合物（EPS）的作用尚未得到很好的研究。我们提出了 EPS 矩阵的数学描述来研究异质生物膜形态的发展。在开发模型时，我们假设生物膜是由 EPS 和水组成的生物凝胶。细菌缠绕在网络中，是聚合物的生产者。为了响应外部条件，凝胶吸收或排出溶剂，由于渗透压梯度而导致膨胀或收缩。生物膜的物理形态取决于温度、溶剂组成、pH 值和渗透压的离子浓度。这为生物膜内生物量的重新分配提供了一种基于物理的机制。简化模型的分析表明，通过膨胀机制，生物量重新分配可能会通过 EPS 产生的空间变化（导致渗透压梯度）诱导孤立塔或蘑菇簇的形成。
Although the initiation, development and control of biofilms has been an area of experimental investigation for more than three decades, the role of extra-cellular polymeric substance (EPS) has not been well studied.We present a mathematical description of the EPS matrix to study the development of heterogeneous biofilm morphology. In developing the model, we assume that the biofilm is a biological gel composed of EPS and water. The bacteria are enmeshed in the network and are the producers of the polymer. In response to external conditions, gels absorb or expel solvent causing swelling or contraction due to osmotic pressure gradients. The physical morphology of the biofilm depends on the temperature, solvent composition, pH and ionic concentrations through osmotic pressure. This gives a physically based mechanism for the redistribution of biomass within the biofilm.Analysis of a reduced model indicates that biomass redistribution, through the mechanism of swelling, may induce the formation of isolated towers or mushroom clusters by spatial variation in EPS production which leads to gradients in osmotic pressure.