Myocyte death in heart failure
Myocyte death in heart failure
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DOI：
10.1097/00001573-199605000-00004
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发表时间：
1996-05-01
影响因子：
2.3
通讯作者：
Olivetti, G
中科院分区：
文献类型：
--
作者：
Anversa, P;Kajstura, J;Olivetti, G
失代偿性离心性心室肥厚是由代偿性压力或容量超负荷肥厚向心肌功能障碍和衰竭转变的特征。心肌细胞丢失是室壁变薄和室腔扩张的主要病因，并可能是心肌病进展的条件。心肌细胞死亡可通过凋亡或坏死发生，但在缺血性起源的病理性心脏中，心肌细胞自杀程序的激活超过坏死细胞死亡。反应性纤维化是否构成心室功能障碍启动的主要事件或肌细胞死亡的次要反应是一个重要的悬而未决的问题。
Decompensated eccentric ventricular hypertrophy characterizes the transition from compensated pressure or volume overload hypertrophy to myocardial dysfunction and failure. Myocyte loss is the major etiologic factor of wall thinning and chamber dilation and may condition the progression of the cardiac myopathy. Myocyte death can occur by apoptosis or necrosis, but the activation of the suicide program of myocytes exceeds necrotic cell death in the pathologic heart of ischemic origin. Whether reactive fibrosis constitutes a primary event in the initiation of ventricular dysfunction or a secondary reaction to myocyte death is an important unanswered question.