Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men
Long-term training induces a healthy inflammatory and endocrine emergent biomarker profile in elderly men
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DOI：
10.1007/s11357-011-9266-9
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发表时间：
2012-06-01
期刊：
影响因子：
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通讯作者：
Coto-Montes, Ana
中科院分区：
文献类型：
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作者：
de Gonzalo-Calvo, David;Fernandez-Garcia, Benjamin;Coto-Montes, Ana
本研究的目的是调查长期训练的老年男性中大量新出现的老年生物标志物的变化，以分析长期运动对老年人的影响。我们收集了两组年龄在65岁以上的男性志愿者的血液样本，他们保持一定程度的功能独立性：一组是久坐不动的受试者，没有规律的身体活动史，另一组是从成年期开始持续训练的受试者（平均训练时间= 49±8年）。我们研究了发病率、多药、细胞和血清学炎症参数和内分泌介质。在调整混杂因素后，我们观察到，长期运动组的人均药物摄入量减少，人均疾病数量减少，统计学差异接近显著。我们发现，长期训练与白细胞计数、中性粒细胞计数、白细胞介素-6、白细胞介素-10、白细胞介素-1受体拮抗剂和可溶性TNF受体-1水平降低有关。此外，我们注意到在长期训练组中胰岛素样生长因子-1和脱氢表雄酮的浓度增加。我们的结论是，从成年到老年的长期运动训练与新兴老年生物标志物的健康状况明显相关。长期训练可以改善与老年男性疾病、虚弱、功能衰退和死亡率相关的炎症-内分泌失衡。我们的研究结果表明，从成年到老年，长期锻炼是有益的。
The objective of the present study was to investigate the changes in a large panel of emergent geriatric biomarkers in long-term trained elderly men to analyze the effects of long-term exercise on an aged population. We collected blood samples from two groups of male volunteers older than 65 years who maintain a measure of functional independence: one group of sedentary subjects without a history of regular physical activity and the other of subjects who have sustained training, starting during adulthood (mean training time = 49 +/- 8 years). We studied morbidity, polypharmacy, cellular and serological inflammatory parameters, and endocrine mediators. After adjusting for confounding factors, we observed reduced medication intake per subject and lower number of diseases per subject with statistical differences nearly significant in the long-term exercise group. We showed that long-term training was associated with lower levels of white blood cell counts, neutrophil counts, interleukin-6, interleukin-10, interleukin-1 receptor antagonist, and soluble TNF receptor-I. Furthermore, we noted an increase in the concentrations of insulin-like growth factor-1 and dehydroepiandrosterone in the long-term training group. We concluded that long-term exercise training from adulthood to old age is clearly associated with a healthy profile of emergent geriatric biomarkers. Long-term training could improve the inflammatory-endocrine imbalance associated with disease, frailty, functional decline, and mortality in elderly men. Our results point to the benefits of prolonged exercise from adulthood to old age.