History of interleukin-4.
History of interleukin-4.
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DOI：
10.1016/j.cyto.2015.01.038
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发表时间：
2015-09
期刊：
影响因子：
3.8
通讯作者：
Paul WE
中科院分区：
文献类型：
--
作者：
Paul WE
IL-4的发现和知识发展的历史阐明了生物医学科学的进步道路。虽然取得了进展，但也有意想不到的曲折，有时进展很快，有时进展太慢。说明性的是从1982年首次报道IL-4到建立阻断IL-4及其同源物IL-13在治疗中度至重度哮喘和特应性皮炎中的功效的延长时间，31年的时期。作者是“在场的创造”，并已参与或见证了几乎所有的主要进展，并在这里叙述了他对这段历史的回忆。
The history of the discovery and the development of our knowledge of IL-4 exemplifies the path of progress in biomedical science. There are unanticipated twists and turns although progress is made, sometimes quickly, other times far too slowly. Illustrative is the extended time from the first report of IL-4 in 1982 to the establishment of the efficacy of blocking IL-4 and its congener IL-13 in the treatment of moderate to severe asthma and atopic dermatitis, a period of 31 years. The author was “present at the creation” and has been a participant or a witness to virtually all the major advances and recounts here his recollection of this history.