FDA-iRISK-A Comparative Risk Assessment System for Evaluating and Ranking Food-Hazard Pairs: Case Studies on Microbial Hazards
FDA-iRISK-A Comparative Risk Assessment System for Evaluating and Ranking Food-Hazard Pairs: Case Studies on Microbial Hazards
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DOI：
10.4315/0362-028x.jfp-12-372
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发表时间：
2013-03-01
影响因子：
2
通讯作者：
Wilson, Margaret
中科院分区：
文献类型：
--
作者：
Chen, Yuhuan;Dennis, Sherri B.;Wilson, Margaret
食品安全体系中的利益相关者，特别是联邦机构，需要循证、透明和严格的方法来评估和比较微生物和化学危害引起的食源性疾病风险以及干预措施对公共卫生的影响。FDA-iRISK（以下简称iRISK）是一个基于Web的定量风险评估系统，正是为了满足这一需求而开发的。该建模工具使用户能够评估，比较和排名在食品供应系统的所有阶段，从初级生产，通过制造和加工，零售分销，并最终到消费者的多个食品危害对所构成的风险。iRISK使用标准的数据输入模板、内置的数学函数和蒙特卡洛模拟技术，整合了来自七个组成部分的数据和假设：食品、危害、消费者人口、描述危害的引入和最终结果的过程模型、消费模式、剂量反应曲线和健康影响。除了风险排名之外，iRISK还使用户能够估计和比较干预措施和控制措施对公共卫生风险的影响。iRISK以各种方式提供拟议干预措施影响的估计，包括平均疾病风险和疾病负担指标的变化，如残疾调整生命年的损失。对单核细胞增生李斯特菌和沙门氏菌进行了案例研究，以证明iRISK在估计风险和微生物危害干预措施的影响方面的应用。iRISK于2012年10月在http://irisk.foodrisk.org上向公众开放。
Stakeholders in the system of food safety, in particular federal agencies, need evidence-based, transparent, and rigorous approaches to estimate and compare the risk of foodborne illness from microbial and chemical hazards and the public health impact of interventions. FDA-iRISK (referred to here as iRISK), a Web-based quantitative risk assessment system, was developed to meet this need. The modeling tool enables users to assess, compare, and rank the risks posed by multiple food-hazard pairs at all stages of the food supply system, from primary production, through manufacturing and processing, to retail distribution and, ultimately, to the consumer. Using standard data entry templates, built-in mathematical functions, and Monte Carlo simulation techniques, iRISK integrates data and assumptions from seven components: the food, the hazard, the population of consumers, process models describing the introduction and fate of the hazard up to the point of consumption, consumption patterns, dose-response curves, and health effects. Beyond risk ranking, iRISK enables users to estimate and compare the impact of interventions and control measures on public health risk. iRISK provides estimates of the impact of proposed interventions in various ways, including changes in the mean risk of illness and burden of disease metrics, such as losses in disability-adjusted life years. Case studies for Listeria monocytogenes and Salmonella were developed to demonstrate the application of iRISK for the estimation of risks and the impact of interventions for microbial hazards. iRISK was made available to the public at http://irisk.foodrisk.org in October 2012.