The transmission of prions to humans
The transmission of prions to humans
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DOI：
10.1111/j.1651-2227.1999.tb14400.x
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发表时间：
1999-12-01
期刊：
影响因子：
3.8
通讯作者：
Will, RG
中科院分区：
文献类型：
--
作者：
Will, RG
1996年，新变异型克雅氏病（nvCJD）的鉴定导致了这种新疾病是由牛海绵状脑病（BSE）传播给人类引起的建议。这一提议的影响是广泛而深刻的，无论是在政治上还是在英国和其他国家的普通公众身上。nvCJD患者表现出一系列一致的临床病理学特征，并且nvCJD病例几乎仅在英国继续报告，英国是迄今为止BSE发病率最高的国家。实验室研究，包括在小鼠中的传播实验，为nvCJD是由BSE引起的假设提供了强有力的支持。
The identification of new-variant Creutzfeldt-Jakob disease (nvCJD) in 1996 led to the proposal that this new disease was caused by the transmission of bovine spongiform encephalopathy (BSE) to the human population. The ramifications of such a proposal have been extensive and profound, both politically and on the general public in the UK and other countries. Patients with nvCJD exhibit a consistent set of clinicopathological features, and cases of nvCJD continue to be reported almost exclusively in the UK, the country with by far the highest incidence of BSE. Laboratory studies, including transmission experiments in mice, provide strong support for the hypothesis that nvCJD is caused by BSE.