Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis.
Effects of administration styles of arsenic trioxide on intracellular arsenic concentration, cell differentiation and apoptosis.
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DOI：
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发表时间：
2005
期刊：
影响因子：
10.1
通讯作者：
Jin Zhou;R. Meng;Xin-hua Sui;L. Meng;J. Jia;Bao-feng Yang
中科院分区：
文献类型：
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作者：
Jin Zhou;R. Meng;Xin-hua Sui;L. Meng;J. Jia;Bao-feng Yang
We studied the effects of varying and steady-state concentrations of arsenic trioxide (As2O3) on apoptosis and differentiation of several cell lines in vitro. We also studied the same effects of fluctuating vs constant concentrations of As2O3 in vivo in patients treated with daily 3-hour fast infusions or daily slow, continuous infusions. Intracellular concentrations of arsenic and apoptosis rate were higher whereas differentiation was reduced in cells exposed to constant concentrations of As2O3.
