Brain activation to phobia-related pictures in spider phobic humans: an event-related functional magnetic resonance imaging study
Brain activation to phobia-related pictures in spider phobic humans: an event-related functional magnetic resonance imaging study
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DOI：
10.1016/s0304-3940(03)00647-5
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发表时间：
2003-09-04
影响因子：
2.5
通讯作者：
Miltner, WHR
中科院分区：
文献类型：
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作者：
Dilger, S;Straube, T;Miltner, WHR
我们利用事件相关功能磁共振成像研究了蜘蛛恐惧症和非蜘蛛恐惧症受试者在暴露于与恐惧相关的图片（蜘蛛）和非恐惧相关的图片（蛇和蘑菇）时血氧水平依赖的大脑激活。与之前的研究相反，我们发现，在呈现与恐惧症相关的视觉刺激时，蜘蛛恐惧症患者的杏仁核激活显著增加，而对照组则没有。此外，在脑岛、眼窝额叶皮层和前额叶中也发现了恐惧症特异性激活的增加。我们的研究证实了杏仁核在恐惧处理中的作用，并为动物恐惧症患者面对与恐惧相关的刺激时大脑的激活模式提供了见解。(C) 2003爱思唯尔科学爱尔兰有限公司。版权所有。
Using event-related functional magnetic resonance imaging we investigated blood oxygen level dependent brain activation in spider phobic and non-phobic subjects while exposed to phobia-related pictures (spiders) and non-phobia-related pictures (snakes and mushrooms). In contrast to previous studies, we show significantly increased amygdala activation in spider phobics, but not in controls, during presentation of phobia-relevant visual stimuli. Furthermore, phobia-specific increased activation was also found in the insula, the orbitofrontal cortex and the uncus. Our study confirms the role of the amygdala in fear processing and provides insights into brain activation patterns when animal phobics are confronted with phobia-related stimuli. (C) 2003 Elsevier Science Ireland Ltd.. All rights reserved.