Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein
Arbidol: A potential antiviral drug for the treatment of SARS-CoV-2 by blocking trimerization of the spike glycoprotein
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DOI：
10.1016/j.ijantimicag.2020.105998
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发表时间：
2020-08-01
影响因子：
10.8
通讯作者：
Vankadari, Naveen
中科院分区：
文献类型：
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作者：
Vankadari, Naveen
严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）大流行是一种全球性的公共卫生紧急情况，需要新的治疗方法。本文报道了阿比朵尔（umifenovir）治疗2019冠状病毒病（COVID-19）的潜在药物靶点和作用机制。分子动力学和结构分析用于显示阿比朵尔如何靶向SARS-CoV-2刺突糖蛋白并阻止其三聚化，这是宿主细胞粘附和劫持的关键，表明阿比朵尔治疗COVID-19的潜力。希望了解阿比朵尔的潜在药物靶点和作用机制将有助于开发SARS-CoV-2的新疗法。(C)2020 Elsevier B. V.和国际化疗学会。All rights reserved.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic is a global public health emergency, and new therapeutics are needed. This article reports the potential drug target and mecha-nism of action of Arbidol (umifenovir) to treat coronavirus disease 2019 (COVID-19). Molecular dynamics and structural analysis were used to show how Arbidol targets the SARS-CoV-2 spike glycoprotein and impedes its trimerization, which is key for host cell adhesion and hijacking, indicating the potential of Arbidol to treat COVID-19. It is hoped that knowledge of the potential drug target and mechanism of action of Arbidol will help in the development of new therapeutics for SARS-CoV-2. (C) 2020 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.