The Prefrontal Cortex Modulates Category Selectivity in Human Extrastriate Cortex
The Prefrontal Cortex Modulates Category Selectivity in Human Extrastriate Cortex
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DOI：
10.1162/jocn.2010.21516
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
D'Esposito, Mark
中科院分区：
文献类型：
--
作者：
Miller, Brian T.;Vytlacil, Jason;D'Esposito, Mark
不同类别的视觉对象在纹外视皮层引起不同的刺激诱发感觉反应。虽然大量的证据支持一个独特的代表性的神经结构，调制的类别选择性的自上而下的影响的机制仍然不确定。在这项研究中，我们调查的因果关系的PFC在调制的诱发活动，以面对和场景刺激的纹外皮层。我们使用了两种实验方法来破坏前额叶皮质功能--健康受试者中的重复TMS到PFC（实验1）和中风患者中的局灶性PFC损伤（实验2）。在这些干扰正常PFC功能（前与后TMS和病变与完整的半球），刺激诱发的活动在纹外皮层表现出不太明显的类别选择性的面孔和场景。这两个实验提供了收敛的证据，突出了PFC在自上而下调制自下而上的视觉信号中的直接作用。
Different categories of visual objects evoke distinct stimulus-evoked sensory responses in extrastriate visual cortex. Although numerous lines of evidence support a distinct representational neural architecture, the mechanisms underlying the modulation of the category selectivity by top-down influences remains uncertain. In this study, we investigate the causal role of the PFC in the modulation of evoked activity to face and scene stimuli in the extrastriate cortex. We used two experimental approaches to disrupt prefrontal cortical function-repetitive TMS to PFC in healthy participants (Experiment 1) and focal PFC lesions in stroke patients (Experiment 2). After these perturbations to normal PFC function (pre- vs. post-TMS and lesion vs. intact hemisphere), stimulus-evoked activity in extrastriate cortex exhibited less distinct category selectivity to faces and scenes. These two experiments provide convergent evidence highlighting a direct role of PFC in the top-down modulation of bottom-up visual signals.