Assessment of Health-Related Quality of Life in Renal Transplant Recipients and Dialysis Patients
Assessment of Health-Related Quality of Life in Renal Transplant Recipients and Dialysis Patients
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DOI：
10.1016/j.transproceed.2010.12.015
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发表时间：
2011-01-01
影响因子：
0.9
通讯作者：
Chkhotua, A.
中科院分区：
文献类型：
--
作者：
Maglakelidze, N.;Pantsulaia, T.;Chkhotua, A.
健康相关生活质量（HRQoL）正在成为评价各种形式肾脏替代治疗（RRT）的重要结局指标。简明健康调查表-36（SF-36）、吉森主观主诉量表（GBB-24）和Zerssen情绪量表（Bf-S）是经国际验证的HRQoL评估问卷。本研究的目的是评价肾移植受者的HRQoL，并将其与接受不同形式RRT的患者进行比较。研究人群包括：（1）120名接受血液透析（HD）的患者;（2）43名接受腹膜透析（PD）的患者;（3）9名失去移植物并重新接受透析的受者;（4）120名年龄和性别匹配的健康个体（对照）;和（5）48名肾移植受者。对照组和移植受者以及HD和PD患者（包括既往移植患者）之间的平均SF-36评分无显著差异。与移植受者和健康受试者相比，透析患者在所有8个SF-36领域的评分显著更差。在所有GBB-24组分中，移植受者的得分显著高于HD和PD患者。在“疲劳倾向”、“肢体疼痛”和“心脏病”这三个方面，接受者的得分明显高于对照组。情绪分析（Bf-S）显示，移植受者和对照组的得分没有差异，显着高于透析患者。HD和PD患者的HRQoL相似，低于一般人群。肾移植显著改善HRQoL至少达到健康个体的水平。移植物丢失与HRQoL显著恶化相关。
Health-related quality of life (HRQoL) is becoming an important outcome measure in evaluation of various forms of renal replacement therapy (RRT). The Short Form-36 (SF-36), Giessen Subjective Complaints List (GBB-24), and Zerssen's Mood Scale (Bf-S) are internationally validated questionnaires for the assessment of HRQoL. The goal of the current study was to evaluate the HRQoL of renal transplant recipients and compare it with that of patients on different forms of RRT. The study population consisted of: (1) 120 patients on hemodialysis (HD); (2) 43 patients on peritoneal dialysis (PD); (3) nine recipients who lost their grafts and went back to dialysis; (4) 120 age- and sex-matched healthy individuals (controls); and (5) 48 renal transplant recipients. The mean SF-36 scores were not significantly different between control group and transplant recipients as well as HD and PD patients including previously transplanted patients. The dialysis patients scored significantly worse in all eight SF-36 domains compared with transplant recipients and healthy subjects. In all GBB-24 components, the transplant recipients scored significantly higher than HD and PD patients. In the "fatigue tendency," "limb pain," and "cardiac complaints" components, recipients scored significantly higher than control group subjects. The mood analysis (Bf-S) showed that the scores of transplant recipients and controls did not differ, being significantly higher than those of dialysis patients. The HRQoL of patients on HD and PD were similar and lower than that of the general population. Renal transplantation significantly improved HRQoL at least to the level of healthy individuals. Graft loss was associated with significant worsening of HRQoL.