Naproxen dose and concentration: response relationship in rheumatoid arthritis.
Naproxen dose and concentration: response relationship in rheumatoid arthritis.
复制标题
萘普生剂量和浓度：类风湿性关节炎的反应关系。
DOI：
10.1093/rheumatology/27.1.48
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
B. Whiting
中科院分区：
文献类型：
--
作者：
F. Dunagan;P. McGill;A. Kelman;B. Whiting
关于非类固醇抗炎药(NSAIDs)的血浆浓度与类风湿关节炎的临床反应之间的关系的信息很少。因此，治疗通常是相对经验性的。标准剂量是开出的，如果明显没有反应，要么会开出另一种药物的处方，要么会增加超过推荐量的剂量。这项研究采用随机双盲设计，对18名服用三种剂量(500、1000和1500 mg/天)的患者进行了为期12天的研究。使用线性模型方法，我们发现四分之三的临床反应测量随着萘普生谷浓度的增加而线性改善，这表明如果萘普生的剂量增加到每天1500毫克，大多数患者的症状将得到改善。然而，由于低谷浓度随着剂量的增加(由于血浆白蛋白上结合部位的饱和)表现出不成比例的增加，所以随着剂量的增加，反应的改善将不那么显著。
Information on the relationship between the plasma concentration of nonsteroidal anti-inflammatory drugs (NSAIDs) and clinical response in rheumatoid arthritis is sparse. As a result treatment is often relatively empirical. Standard doses are prescribed and an apparent lack of response leads either to the prescription of another drug, or an increase in the dose beyond that recommended. This study investigated 18 patients given three doses (500, 1000 and 1500 mg/day) of naproxen in a randomized double-blind design for 12 days at a time. Using a linear modelling approach we found that three out of four clinical response measurements improved linearly with increasing naproxen trough concentrations, suggesting that most patients will achieve an improvement in symptoms if the dose of naproxen is increased up to 1500 mg/day. However, since trough naproxen concentrations show a less than proportional increase with increasing dose (due to saturation of binding sites on plasma albumin), the improvement in response will be less dramatic as the dose is increased.