ANTIGENICITY OF THE RABBIT HEMORRHAGIC-DISEASE VIRUS STUDIED BY ITS REACTIVITY WITH MONOCLONAL-ANTIBODIES
ANTIGENICITY OF THE RABBIT HEMORRHAGIC-DISEASE VIRUS STUDIED BY ITS REACTIVITY WITH MONOCLONAL-ANTIBODIES
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DOI：
10.1016/0168-1702(95)00033-m
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发表时间：
1995-08-01
期刊：
影响因子：
5
通讯作者：
ROSSI, C
中科院分区：
文献类型：
--
作者：
CAPUCCI, L;FRIGOLI, G;ROSSI, C
制备了一组抗兔出血症病毒（RHDV）的单克隆抗体，并对其进行了表征。测定了单克隆抗体识别RHDV衣壳、欧洲褐兔综合征病毒衣壳和RHDV亚单位上存在的表位的能力。通过体内保护实验获得了关于单克隆抗体的中和能力的初步结果。本研究获得的RHDV抗原图与目前杯状病毒结构模型一致。
A panel of anti-rabbit hemorrhagic disease virus (anti-RHDV) monoclonal antibodies was produced and characterized. The ability of the MAbs to recognize epitopes present on RHDV capsids, European brown hare syndrome virus capsids and RHDV subunits was determined. Preliminary results on the neutralizing capacity of the MAbs were obtained by in vivo protection experiments. The antigenic map of RHDV obtained by this study is consistent with the current models of the calicivirus structure.