KINETICS OF PCB ELIMINATION IN MAN
KINETICS OF PCB ELIMINATION IN MAN
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DOI：
10.1016/0045-6535(88)90099-9
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发表时间：
1988-01-01
期刊：
影响因子：
8.8
通讯作者：
SCHLATTER, C
中科院分区：
文献类型：
--
作者：
BUHLER, F;SCHMID, P;SCHLATTER, C
制备类似于技术产品Aroclor 1254的均匀13 C标记的PCB混合物。一名志愿者经口摄入了329 μg/kg bw的该混合物。在260天的时间内采集血液样品，并使用GC/MS和GC/ECD分析13 C-和12 C-PCB的浓度。异构体的消除遵循一级动力学。异构体138（22′344′5′-六氯联苯）、153（22′44′55′-六氯联苯）和180（22′344′55′-七氯联苯）的半衰期分别为321、338和124天。
A uniformly13C-labeled PCB mixture similar to the technical product Aroclor 1254 was prepared. Of this mixture a single dose of 329 μg/kg bw was orally ingested by a volunteer. Blood samples were taken during a period of 260 days and analysed for the concentrations of13C- and12C-PCB using GC/MS and GC/ECD. Elimination of the isomers followed first order kinetics. The half-lives for the isomers 138 (22′344′5′-hexachlorobiphenyl), 153 (22′44′55′-hexachlorobiphenyl) and 180 (22′344′55′-heptachlorobiphenyl) were 321, 338, and 124 days respectively.